<strong>Cu</strong>对<strong>Ni-Ti</strong>合金抗支架内再狭窄与耐蚀性能的影响

doi:10.11900/0412.1961.2022.00553

金属学报

2023, Vol. 59

Issue (4): 577-584 DOI: 10.11900/0412.1961.2022.00553

研究论文

本期目录 | 过刊浏览

Cu对Ni-Ti合金抗支架内再狭窄与耐蚀性能的影响

许林杰¹^,², 刘徽¹, 任玲¹, 杨柯¹(

)

¹中国科学院金属研究所沈阳 110016
²中国科学技术大学材料科学与工程学院沈阳 110016

Effect of Cu on In-Stent Restenosis and Corrosion Resistance of Ni-Ti Alloy

XU Linjie¹^,², LIU Hui¹, REN Ling¹, YANG Ke¹(

)

¹Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China
²School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China

引用本文:

许林杰, 刘徽, 任玲, 杨柯. Cu对Ni-Ti合金抗支架内再狭窄与耐蚀性能的影响[J]. 金属学报, 2023, 59(4): 577-584.
Linjie XU, Hui LIU, Ling REN, Ke YANG. Effect of Cu on In-Stent Restenosis and Corrosion Resistance of Ni-Ti Alloy[J]. Acta Metall Sin, 2023, 59(4): 577-584.

全文: PDF(1719 KB) HTML

摘要:

基于合金化策略，通过向医用Ni-Ti合金中添加适量Cu制备生物功能化Ni-Ti-Cu合金，并利用OM、SEM、XRD、表面自由能测试、电化学实验以及体外细胞实验等方法，探究Ni-Ti-Cu合金抑制支架内再狭窄作用以及耐蚀性能。结果表明，与Ni-Ti合金相比，Ni-Ti-Cu合金由等轴奥氏体组织向细板条马氏体组织转变，其表面自由能显著降低，在模拟人体血液中的耐蚀性能提高。此外，Ni-Ti-Cu合金浸提液还可显著促进人脐静脉内皮细胞的增殖、迁移及成血管能力。与Ni-Ti合金相比，Ni-Ti-Cu合金可降低血液凝固速率，表现出更优异的抗凝血性能，具有抑制支架内再狭窄发生的应用潜力。

关键词 ： Ni-Ti合金, Cu, 支架内再狭窄, 耐蚀性能

Abstract：

Ni-Ti alloys are used widely as a self-expanding vascular stent material because of their unique shape memory effect and superelasticity. However, after implantation, there is a risk of in-stent restenosis (ISR) because of insufficient endothelialization and coagulation problems. As a biological functional metal element, the proper addition of Cu endows vascular stent materials, such as stainless steel and cobalt-based alloys, with significant endothelialization promotion and anticoagulant effect, which can effectively inhibit the occurrence of ISR. Based on the alloying strategy, a biofunctional Ni-Ti-Cu alloy was prepared by adding the proper amount of Cu into medical Ni-Ti alloys. The inhibition effect of ISR and corrosion resistance of the Ni-Ti-Cu alloy were studied via OM, SEM, XRD, surface free energy test, electrochemical test, and in vitro cell experiment. Results showed that compared with the Ni-Ti alloy, the Ni-Ti-Cu alloy promoted the transformation of an equiaxed austenite grain structure to fine lath martensite, reduced the surface free energy, and improved corrosion resistance in simulated human blood. In addition, the extract of the Ni-Ti-Cu alloy could promote the proliferation, migration, and tube formation of human umbilical vein endothelial cells. Furthermore, compared with the Ni-Ti alloy, the Ni-Ti-Cu alloy decreased the blood coagulation rate, presenting better anticoagulation ability, which has an application potential for inhibiting the occurrence of ISR.

Key words： Ni-Ti alloy Cu in-stent restenosis corrosion resistance

收稿日期: 2022-10-31

ZTFLH:

TG146.23

基金资助:国家重点研发计划项目(2022YFC2406003);国家自然科学基金项目(81873918);国家自然科学基金项目(82272099);辽宁省自然科学基金计划项目(2021020399-JH2/103);辽宁省自然科学基金计划项目(2022-YGJC-34)

通讯作者: 杨柯，kyang@imr.ac.cn，主要从事新型医用金属材料研发及应用研究、先进钢铁材料研究以及储氢合金研究

Corresponding author: YANG Ke, professor, Tel: (024)23971628, E-mail: kyang@imr.ac.cn

作者简介: 许林杰，男，1999年生，硕士生

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https://www.ams.org.cn/CN/10.11900/0412.1961.2022.00553 或 https://www.ams.org.cn/CN/Y2023/V59/I4/577

图1 Ni-Ti和Ni-Ti-Cu合金的XRD谱与SEM像

Alloy	θ₁ / (°)	θ₂ / (°)	θ₃ / (°)	$γ s v p$ / (mJ·m^-2)	$γ s v d$ / (mJ·m^-2)
Ni-Ti	53.44 ± 1.94	55.53 ± 3.27	18.59 ± 0.37	11.94 ± 1.31	39.31 ± 0.83
Ni-Ti-Cu	58.36 ± 3.60	65.73 ± 3.58	19.12 ± 0.88	8.99 ± 1.12	37.56 ± 1.08

表1 不同样品与去离子水、甘油和溴代萘的接触角及表面自由能测量结果

图2 Ni-Ti和Ni-Ti-Cu合金的电化学测试结果

表2 从动电位极化曲线与EIS图中获得的电化学参数

图3 Ni-Ti和Ni-Ti-Cu合金的体外细胞实验结果

图4 Ni-Ti和Ni-Ti-Cu合金的动态凝血实验结果

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