Bone Induction of a Biodegradable Magnesium Alloy

Acta Metall Sin

2008, Vol. 44

Issue (9): 1035-1041 DOI:

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Bone Induction of a Biodegradable Magnesium Alloy

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中科院金属研究所

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. Bone Induction of a Biodegradable Magnesium Alloy. Acta Metall Sin, 2008, 44(9): 1035-1041 .

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Abstract AZ31B magnesium alloy samples with two dimensions (stabilization splint and dictyo-plate) were implanted on the submaxilla surface of the New-Zealand rabbits, with comparison of Ti-6Al-4V titanium alloy as a control. Two kinds of bone coloboma were made on the submaxilla surface in order to model the different areas of bone defect. It was found from the experiments, after 3 and 6 months, that newly formed bone around the AZ31B magnesium alloy stabilization splint was much more than the control group. After 6 months, both newly formed bone and osteolysis were found on the surface of the dictyo-plate implants. It can be concluded that magnesium alloy implantation is beneficial to the new bone formation, but overdose of magnesium ions from biodegradation can also lead to the increase of osteoclast activity.

Key words: magnesium alloy degradable materials metal medical materials bone induction

Received: 18 February 2008

ZTFLH:	TG146.2
	R318.08

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[1]Mark P S,Alexis M P,Jerawala H,George D.Biomateri- als,2006 ;27:1728
[2]Erbel R,Di M C,Bartunek J,Bonnier J,de Bruyne B, Eberli F R,Erne P,Haude M.Lancet,2007;369:186
[3]Witte F,Fischer J,Nellesen J,Crostack H A,Kaese V, Pisch A,Beckmann F,Windhagen H.Biomaterials,2006; 27:1013
[4]Witte F,Ulrich H,Rudert M,Willbold E.J Biomed Mater Res,2007;81:748
[5]Witte F,Ulrich H,Palm C,Willbold E.J Biomed Mater Res,2007;81:757
[6]Vonder H N,Krause A,Hackenbroich C,Bormann D,Lu- cas A,Meyer-Lindenberg A.Dtsch Tierarztl Wochenschr, 2006;113:439
[7]Waselau1 M,Samii V F,Weisbrode S E,Litsky A S,Bertone A L.Am J Vet Res,2007;68:370
[8]Agrawal C M,Athanasiou K A.J Biomed Mater Res, 1997;38:105
[9]Kuwahara H,Al-Abdullat Y,Mazaki N,Tsutsumi S, Aizawa T.Mater Trans,2001;42:1317
[10]Zhang G D,Huang J J,Yang K,Zhang B C,Ai H J.Acta Metall Sin,2007;43:1186 (张广道，黄晶晶，杨柯，张炳春，艾红军．金属学报，2D07；43：1186)

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