The newly developed high-performance cast-wrought alloys have been widely applied in advanced turbine engines in recent years, particularly, served as turbine disc and compressor disc. The significant breakthrough has been made on the processing techniques for these highly alloyed disc alloys, including the triple-melting of the large-scale ingots with the diameter more than 500 mm, conversion of the large-scale ingot and the processing of fine-grained billets with the diameter more than 300 mm, customization of the microstructures and properties of disc forgings. The chemical compositions can be well controlled on vacuum arc remelting (VAR) ingots, including the ultra-low carbon content lower than 0.011%. The white spots and freckles have been found to be the primary defects on large-scale VAR ingots, which is triggered by the improper re-melting parameters. The metallurgical defects can be identified on fine-grained billets via supersonic inspection. The investigations have shown that the existence of the micro-duplex structure opens a window for the processing of these highly alloyed disc alloys with up to more than 60% mass fraction of precipitates. Via a multicycle thermal-mechanical processing technique, the hot working process of the disc alloys, can be achieved in a cost-effective way, and the un-recrystallized grains can also be eliminated efficiently. The above-mentioned techniques have greatly promoted the development and application of the high-performance disc alloys, such as GH4065, GH4720, GH4175 and GH4975, et al. These alloys can provide a promising solution of high reliability combined with low life cycle cost for military and commercial gas turbines. Nonetheless, in order to maximize the advantageous of cast-wrought disc alloys on reliability and cost-effective ratio, the comprehensive understanding about the prevention and identification of metallurgical defects, increase in the yield rate of materials during conversion, processing of fine-grained billets and dual-property disc forgings, is still needed.