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Acta Metall Sin  2017, Vol. 53 Issue (10): 1197-1206    DOI: 10.11900/0412.1961.2017.00279
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Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes
Jiahui DONG1,2, Lili TAN1, Ke YANG1()
1 Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China
2 School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China
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Abstract  

Bone defects are very challenging in orthopedic practice due to a variety of reasons. Bone repair requires four critical elements, biocompatibility, osteoconduction, osteoinduction and osteogenesis. The autografts still exist some problems for applications such as the limitation of available autogenous bones and post-operative complications, although they are considered as the “gold standard” in bony defect repairs. Generally the synthetic bone substitutes do not possess osteoinductive and osteogenic activities. Therefore, the clinical bone grafts and bone-graft substitutes have their own shortcomings in the repair of bone defects. Biodegradable magnesium-based metals, including pure magnesium and magnesium alloys, have been concerned and studied recently due to their biodegradation, good biocompatibility and similar elastic modulus and density with bone tissue. This paper summarizes the biological behavior of magnesium-based metals for bone defects repair application, including ability of promoting osteogenesis, osteoconduction and potential osteoinduction, as well as some particular biofunctions such as antibacterial and antitumor properties. The great advantages and potentials of magnesium in bone defects repair can not be denied as a promising class of bone substitutes, although further researches are still needed for clinical applications.

Key words:  bone defect      bone repair      osteogenesis      Mg-based metal      biodegradable     
Received:  06 July 2017     
ZTFLH:  R318.08  
Fund: Supported by National Natural Science Foundation of China (Nos.81401773 and 31500777)

Cite this article: 

Jiahui DONG, Lili TAN, Ke YANG. Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes. Acta Metall Sin, 2017, 53(10): 1197-1206.

URL: 

https://www.ams.org.cn/EN/10.11900/0412.1961.2017.00279     OR     https://www.ams.org.cn/EN/Y2017/V53/I10/1197

Fig.1  The comparison of compressive strength for natural bone, commercial bone-grafting products and magnesium-based metals[21]
Fig.2  HE stained bone surrounding Mg-6Zn rods for 6 weeks (a) and 18 weeks (b) post-implantation[26]
Fig.3  CT reconstructions (3-D display) of the bone defects: Mg alloy after 2 months (a) and 4 months (c); CaSO4 after 2 months (b) and 4 months (d)[27]
Fig.4  Schematic diagram shows osteogenic differentiation of periosteum-dirved stem cells (PDSC) induced by implant-derived Mg2+ [29]
Fig.5  Histological work-up of the specimens (The ?gure gives an example of ultrathin grindings stained according to the Laczkó-Lévai staining technique, showing pink-staining bone, blue-staining cartilage and grey-staining ?brous tissue)[37]
Fig.6  Histological thin slides of ZX50 (a, c, e, g) and WZ21 (b, d, f, h) pins in a Levai-Laczko staining[39]
Fig.7  The colony-forming unit (CFU)/mL of S. aureus suspension after incubation with different samples[40]
Fig.8  The hydrogen release volumes of P-Mg and AH-Mg samples as a function of the immersion time in SBF (a), the OD values of hydroxyl radical concentration in different systems (b), the relative optical dersity (OD) values of free radicals concentration in MG63 cultured on P-Mg and AH-Mg samples for 4, 6, and 8 h (c)[51]
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