Research and Application of Biomedical Nickel-Free Stainless Steels

doi:10.11900/0412.1961.2017.00268

Acta Metall Sin

2017, Vol. 53

Issue (10): 1311-1316 DOI: 10.11900/0412.1961.2017.00268

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Research and Application of Biomedical Nickel-Free Stainless Steels

Qingchuan WANG, Bingchun ZHANG, Yibin REN, Ke YANG(

)

Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

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Qingchuan WANG, Bingchun ZHANG, Yibin REN, Ke YANG. Research and Application of Biomedical Nickel-Free Stainless Steels. Acta Metall Sin, 2017, 53(10): 1311-1316.

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Abstract

Biomedical nickel-free stainless steels acquire better comprehensive properties than the traditional stainless steels, with wide application prospect in medical devices for bone and vascular repair. As a new biomaterial, in recent years, the excellent properties of nickel-free stainless steels are gradually verified, which is meaningful for developing medical devices with higher safety and biocompatibility. In this paper, the research progress on alloy design, mechanical properties, corrosion resistance and biocompatibility of nickel-free stainless steels and the current application status are reviewed, and the future tendency on research and development for this new metallic biomaterial is also proposed.

Key words: biomedical stainless steel nickel-free high nitrogen bone repair vascular stent

Received: 03 July 2017

ZTFLH:	TG142.71
	R318.00

Fund: Supported by National Natural Science Foundation of China (No.31370976)

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	Qingchuan WANG
	Bingchun ZHANG
	Yibin REN
	Ke YANG

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https://www.ams.org.cn/EN/10.11900/0412.1961.2017.00268 OR https://www.ams.org.cn/EN/Y2017/V53/I10/1311

Fig.1 Constitution diagram for high nitrogen nickelfree stainless steel (HNS) summarized from data of experimental and commercial stainless steels[18] (Solid symbols represent full austenite,opensymbolsrepresent d-ferrite+austenite)

Fig.2 Potentiodynamic curves of 0.76%N (mass fraction) (a) and 0.92%N (b) HNS under different cold working levels^[39]

Fig.3 Histological and biomechanical analyses of bone-implant interfaces^[43]
(a) histological observation of undecalcified sections: pink tissue-old bone (OB) and crimson tissue-new bone (NB)
(b) percentage of bone-implant contact and new bone area from the histomorphometric measurements (^a—p<0.05, ^b—p<0.01 when compared to 316L SS; P.I—post implantation)
(c) bonding strength at bone-implant interfaces from push-out test (*—p<0.05)

Fig.4 Neointima formation after coronary stenting in pig was reduced by high nitrogen Ni-free stainless steel stent after 28 d implantation^[51]
(a) percentage of in-stent restenosis evaluated using angiography; n=20 and 17 in the 316L and Ni-free stents groups, respectively (*—p<0.05)
(b) representative sections of stented arteries stained with hematoxylin/eosin (L—lumen, N—neointima, M—media)

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