With increasing power of aero-engines, the effects of temperature and load on hot-end parts such as bearings and bushings are becoming more apparent, leading to the wear failure of hot-end parts. Therefore, increasing the wear resistance of hot-end parts is very important. Laser-clad coatings can considerably improve the mechanical properties and wear resistance of these parts, without altering the properties of the substrate. The use of such coatings provides a new approach to improve the high-temperature wear resistance of hot-end parts. Mo alloys with high melting point, excellent high-temperature strength, and low thermal expansion coefficient have been widely used as high-temperature materials. Therefore, these coatings fabricated using the laser cladding technology have good prospects for application as wear-resistant coatings on the surface of hot-end parts at elevated temperatures. To further enhance the wear resistance of the Mo alloy coatings for application as high-temperature protective coatings for hot-end parts, MoNiCrSi coatings were in situ prepared on the surface of the Inconel 718 alloy via laser cladding. The effects of Si on the microstructure and high-temperature tribological performance of the Mo alloy coatings were systematically studied. The high-temperature wear tests of the Mo alloy coatings and Inconel 718 alloy were performed using a ball-on-disk tribo-tester against Si₃N₄ balls in an environment where the temperature varied from room temperature to 1000 ^oC. The results indicate that Si reacts with Mo, Ni, and Cr to form α-Mo, Mo_0.3Ni_0.24Si_0.76, Mo₅Si₃, and CrSi₂ phases. Compared with the MoNiCr coating and substrate, the MoNiCrSi coating has higher microhardness. The introduction of Si causes solid solution strengthening and dispersion strengthening effects. The friction coefficients of coatings gradually decrease with increasing temperature. The wear rates firstly decrease and then increase with increasing temperature. Furthermore, with an increase in the temperature, the substrate material exhibits the highest wear rates, reaching a maximum value of 3.41 × 10^-4 mm³/(N·m) at room temperature (24 ^oC). However, the high-temperature wear resistance of the MoNiCrSi coating is the best than that of the MoNiCr coating or substrate, and the wear rates of the MoNiCrSi coating are in the order of magnitude of 10^-6-10^-5 mm³/(N·m) in the temperature range from room temperature to 1000 ^oC. This finding indicates that the introduction of Si drastically improves the high-temperature wear resistance and self-lubricating properties of the Mo alloy coating at elevated temperatures. This improvement is primarily attributed to the synergistic effects of the high hardness of the coatings and introduction of solid lubricants, such as SiO₂, MoO₃, Mo₄O₁₁, and NiMoO₄, as well as an oxide lubricating layer on wear tracks. In particular, at 600 ^oC, the MoNiCrSi alloy coating has the lowest wear rate of 5.57 × 10^-6 mm³/(N·m), which is one order of magnitude lower than that of the MoNiCr coating. The Mo alloy coatings exhibit various wear mechanisms at different temperatures. At room temperature, the main wear mechanisms are fatigue wear, abrasive wear and plastic deformation. At 600 ^oC, the oxidation wear, fatigue wear, and abrasive wear become the primary wear mechanisms. At 1000 ^oC, the dominant wear mechanism of the coatings is oxidative wear.