可降解医用镁合金在骨修复应用中的研究进展

doi:10.11900/0412.1961.2017.00247

金属学报

2017, Vol. 53

Issue (10): 1168-1180 DOI: 10.11900/0412.1961.2017.00247

研究论文

本期目录 | 过刊浏览

可降解医用镁合金在骨修复应用中的研究进展

袁广银¹(

), 牛佳林^1,²

1 上海交通大学轻合金精密成型国家工程研究中心和金属基复合材料国家重点实验室上海 200240
2 沪创医疗科技(上海)有限公司上海 200232

Research Progress of Biodegradable Magnesium Alloys for Orthopedic Applications

Guangyin YUAN¹(

), Jialin NIU^1,²

1 National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China
2 Shanghai Innovation Medical Technology Co., Ltd., Shanghai 200232, China

引用本文:

袁广银, 牛佳林. 可降解医用镁合金在骨修复应用中的研究进展[J]. 金属学报, 2017, 53(10): 1168-1180.
Guangyin YUAN, Jialin NIU. Research Progress of Biodegradable Magnesium Alloys for Orthopedic Applications[J]. Acta Metall Sin, 2017, 53(10): 1168-1180.

全文: PDF(6632 KB) HTML

摘要:

镁合金可在人体内完全降解,其弹性模量与人皮质骨接近,可有效避免应力遮挡效应,且具有较高的机械强度和良好的骨诱导性,因此镁合金作为骨修复材料具有很好的应用潜力,并受到广泛研究。本文对可降解医用镁合金材料在骨修复领域的研究进行了总结,分别从镁合金骨修复材料的优势,发展历史,存在的问题与挑战,近几年的研究进展等几个方面进行了阐述。文章最后介绍了上海交通大学轻合金精密成型国家工程研究中心团队在骨修复用镁合金方面的最新研究成果,以及为推动我国可降解医用镁合金的产业化进程方面所做的工作。

关键词 ：可降解医用镁合金, 骨修复, 生物降解性能, 生物相容性

Abstract：

Magnesium and its alloys exhibit high mechanical strength and good biocompatibility, and their modulus is similar to natural cortical bone, which could help to avoid the stress shielding effect. These advantages make them promising candidates for bone repair applications. This paper summarizes the advantages, history, challenges, and the recent research progress of biodegradable Mg alloys for orthopedic application. At last, it gives a detailed introduction of the latest researches of Shanghai Jiao Tong University on biodegradable Mg alloys, and related work to promote their clinical applications.

Key words： biodegradable Mg-based alloy bone fixation biodegradation behavior biocompatibility

收稿日期: 2017-06-22

ZTFLH:

TG146.22

基金资助:国家高技术研究发展计划项目No.2015AA033603,国家自然科学基金项目No.51571143,上海市科委企业国际合作项目No.17440730700,2017年度上海市优秀学术带头人计划No.17XD1402100

作者简介:

作者简介袁广银,男, 1970年生,教授

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图1 镁离子促成骨机理示意图[13]

图2 德国Syntellix公司生产的MAGNEZIX?镁合金空心加压螺钉应用于脚拇指外翻手术[30]

图3 韩国U&i公司生产的K-MET镁合金螺钉应用手部骨折手术[33]

图4 JDBM和JDBM-DCPD样品照片

图5 JDBM和JDBM-DCPD骨板骨钉以及兔子胫骨骨折内固定手术

图6 JDBM和JDBM-DCPD螺钉植入兔子胫骨的降解形貌[92]

图7 骨板四点弯曲测试装置,及 JDBM、JDBM-DCPD和WE43骨板植入兔子胫骨不同时间后弯曲强度变化

图8 兔子下颌骨骨折内固定手术[93]

图9 JDBM-DCPD螺钉植入兔子颌骨后不同时间的降解剩余形貌[94]

图10 JDBM-DCPD螺钉植入18个月后组织切片观察[94]

图11 JDBM表面PLA/DCPD复合涂层的制备及其性能评价[95]

图12 沪创医疗科技(上海)有限公司生产的JDBM骨钉骨板产品原型

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