Experimental Study of in Vivo Implantation of a Magnesium Alloy at Early Stage

Acta Metall Sin

2007, Vol. 43

Issue (11): 1186-1190 DOI:

Research Articles

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Experimental Study of in Vivo Implantation of a Magnesium Alloy at Early Stage

ZHANG Guangdao1); HUANG Jingjing2);YANG Ke2); ZHANG Bingchun2); AI Hongjun1)

1) School of Stomatology; China Medical University 2) Institute of Metal Research; Chinese Academy of Sciences

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ZHANG Guangdao; HUANG Jingjing; YANG Ke; ZHANG Bingchun; AI Hongjun. Experimental Study of in Vivo Implantation of a Magnesium Alloy at Early Stage. Acta Metall Sin, 2007, 43(11): 1186-1190 .

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Abstract In order to study the effect of magnesium alloy on the animals, the AZ31B magnesium alloys with different dimensions were implantated in the New-Zealand rabbits, with a titanium alloy（Ti-6Al-4V) as a control. It was found from the experiments that the osteotylus was found surround the magnesium alloy after 2 weeks implantation, and it turned into ripe bone tissue at 8 weeks. The implantation of the magnesium alloy did not influence the recirculating, immune and urinary systems of the rabbit. The magnesium calcium apatite, which was the main degradation product of the magnesium alloy, could be metabolismed by the kidney. The magnesium ions concentration in blood was in the range of normal values. It can be concluded that it is safe for the rabbit in the early stage of the magnesium alloy implantation, and the implant can be beneficial to the new bone formation.

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Received: 01 March 2007

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	ZHANG Guangdao
	HUANG Jingjing
	YANG Ke
	ZHANG Bingchun
	AI Hongjun

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https://www.ams.org.cn/EN/ OR https://www.ams.org.cn/EN/Y2007/V43/I11/1186

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