Preparation and Properties of Biological Functional Magnesium Coating on Ti6Al4V Substrate

doi:10.11900/0412.1961.2017.00285

Acta Metall Sin

2018, Vol. 54

Issue (6): 943-949 DOI: 10.11900/0412.1961.2017.00285

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Preparation and Properties of Biological Functional Magnesium Coating on Ti6Al4V Substrate

Xiaoming YU¹, Lili TAN¹(

), Zongyuan LIU¹, Ke YANG¹, Zhonglin ZHU², Yangde LI³

1 Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China
2 Jiangsu OKANI Medical Technology Co., Ltd., Suzhou 215123, China
3 Dong Guan EONTC Co., Ltd., Dongguan 523808, China

Cite this article:

Xiaoming YU, Lili TAN, Zongyuan LIU, Ke YANG, Zhonglin ZHU, Yangde LI. Preparation and Properties of Biological Functional Magnesium Coating on Ti6Al4V Substrate. Acta Metall Sin, 2018, 54(6): 943-949.

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Abstract

Currently, metallic biomaterials used in orthopedics are normally bioinert which is hard to integrate with the bone tissue inducing aseptic loosening and easy to get infection, which is the main reason of implantation failure. Mg base metals are considered to be a new generation of revolutionary metallic biomaterials due to its similar density and mechanical properties with natural bone, good biocompatibility, degradability in the body as well as the biological functional ability to promote new bone tissue formation. In addition, the degradation of Mg may increase the local pH which can inhibit the growth of bacteria. In this work, pure Mg coating was deposited on Ti6Al4V substrate by arc ion plating. The effects of different working pressures on the surface quality and properties of Mg coating were investigated. The degradation, antibacterial and biosafety properties were studyied. The results showed that the pure Mg coating can be deposited on the surface of Ti6Al4V substrate and the coating was uniform and smooth. The immersion test in vitro showed that the degradation was very fast because of galvanic corrosion, and the whole process was finished in about one week. The results of antimicrobial experiments showed that the Mg coating can kill staphylococcus aureus and showed good antibacterial function. The results of cytotoxicity test showed that Mg coating promoted rabbit bone marrow mesenchymal stem cells (rBMSCs) growth and proliferation.

Key words: Ti alloy pure Mg coating bioproperty

Received: 10 July 2017

ZTFLH:

TB741

Fund: Supported by National Natural Science Foundation of China (Nos.51631009, 81500897 and 81400528) and National Key Research and Development Program of China (No.2016YFC1101804)

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	Xiaoming YU
	Lili TAN
	Zongyuan LIU
	Ke YANG
	Zhonglin ZHU
	Yangde LI

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https://www.ams.org.cn/EN/10.11900/0412.1961.2017.00285 OR https://www.ams.org.cn/EN/Y2018/V54/I6/943

Fig.1 Schematic of the arc ion plating system

Fig.2 XRD patterns of Mg coatings on Ti alloy gained at different pressures

Fig.3 Surface (a~d) and cross section (e) SEM images of Mg coatings on Ti alloy at pressures of 10^-3 Pa (a), 10^-2 Pa (b), 10^-1 Pa (c) and 10⁰ Pa (d, e)

Fig.4 pH curves of Hank's solution immersed with Mg coatings gained at different pressures

Fig.5 Ion release of magnesium coating gained at 10⁰ Pa (single day release)

Fig.6 Antibacterial effects of Ti alloy (a~c) and coated with Mg (d~f) co-cultured with S.aureus at 37 ℃ for 6 h (a, d), 12 h (b, e) and 24 h (c, f)

Fig.7 Cell viabilitiy of titanium alloy coated with Mg and titanium alloy incubated with rBMSCs cells after 1, 2 and 3 d under different dilution ratios

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