As a type of structure functional high temperature alloy, the ignition resistance performance of fireproof titanium alloy is an important basis for the safety in the application. In this work, the relationship between the friction contact pressure P and oxygen concentration c₀ of mixed airflow was established to describe the ignition resistance of fireproof titanium alloys. The ignition resistance of the traditional titanium alloys and typical Ti-V-Cr type titanium alloys was investigated and compared. Based on the principle of friction-induced heat and the thermal explosion theory of ignition, the mechanism of the ignition resistance of fireproof titanium alloys was modeled, calculated and analyzed. The results showed that Ti40 was ignited immediately at room temperature as c₀≥70%. The ignition resistance of Ti40 was 2.5% lower than that of Alloy C⁺ and 40% higher than that of TC4. The ignition originated from the micro-tip formed during friction and the chemical adsorption of oxygen on the micro-tip was the key step for the interaction. With increasing of equivalent pressure P_eq, the critical temperature T ^* ignited by friction decreasd. When P_eq varied from 0.1 to 0.5 MPa, T ^* of Ti40 ranged from 1073 to 1323 K. The surface under friction was 2~5 μm and composed of the fusion of the oxides including TiO₂, V₂O₅ and Cr₂O₃. The lubrication condition between the contacting surfaces was improved by the fused layer and resulted in great temperature decrease in the friction area. Consequently, the ignition resistance of fireproof titanium alloys was improved.