Osteogenic and Antibacterial Metal-Polyphenol Drug-Loaded Coating on Biodegradable Zinc for Orthopedic Implants Application
Received date: 2023-02-02
Revised date: 2023-03-31
Online published: 2023-04-13
Supported by
National Key Research and Development Program of China(2016YFC1102500);Science and Tech-nology Program of Sichuan Province(2020YFH0077);Science and Tech-nology Program of Sichuan Province(2024YFHZ0310);Open Fund Project of Sichuan Provincial Key Laboratory for Material Corrosion and Protection(2022CL07)
Biodegradable metallic Zn materials are being considered for orthopedic implant applications because of their moderate degradation rate and potential bio-functionalities. Nevertheless, their clinical use is limited due to inadequate osteogenic properties owing to Zn2+ burst release, premature mechanical failure caused by non-uniform corrosion, and poor antibacterial ability. Therefore, to overcome these issues, a metal-polyphenol drug-loaded coating was functionalized on the surface using an alternating chemical deposition method out of tannic acid/metformin molecules and active metallic ions via coordination/chelation reactions. The coating was characterized by homogeneous compactness, which enhanced the corrosion resistance of the Zn substrate, adjusted the corrosion mode, suppressed the release of Zn2+, and regulated metformin release. The in vitro pre-osteoblasts (MC3T3-E1) culture results showed that the coated Zn samples exhibited excellent osteogenic ability. The antibacterial assays with coated Zn samples demonstrated strong antibacterial efficiency.
LIN Xue , QIAN Junyu , ZHANG Wentai , WANG Peng , WAN Guojiang . Osteogenic and Antibacterial Metal-Polyphenol Drug-Loaded Coating on Biodegradable Zinc for Orthopedic Implants Application[J]. Acta Metall Sin, 2024 , 60(11) : 1545 -1558 . DOI: 10.11900/0412.1961.2023.00035
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