为了解决镁合金材料降解速率过快、强韧性不匹配和抗菌性不足等问题，本工作基于低合金化设计理念开发了挤压态Mg-Ag-In合金，研究了抗菌低合金化Mg-1Ag-0.5In合金的微观组织特性、力学性能、腐蚀行为、成骨细胞相容性和抗菌性。结果表明，挤压态Mg-1Ag-0.5In合金具有良好的强度和塑性协同性，这主要与拉伸孪晶的协调变形和多滑移模式有关。合金由腐蚀前期的点蚀和丝状腐蚀逐渐转变为单一的丝状腐蚀模式，降低了腐蚀速率，形成更致密的腐蚀产物膜。合金的腐蚀驱动力主要与晶粒取向和高核平均取向差区域的分布有关。挤压态Mg-1Ag-0.5In合金表现出良好的成骨细胞相容性，促进了成骨细胞的增值，同时其具备优异的抗菌性。

Magnesium alloys are regarded as highly promising biomaterials for medical applications due to their low density, high strength, excellent biocompatibility, and ability to degrade safely within the human body. China, which possesses the world’s largest magnesium reserves, has a significant resource advantage for the research and development of medical magnesium alloys. In recent years, China has faced an increasingly severe societal challenge—population aging—which has led to a growing demand for biomaterials, particularly bone implant materials. However, existing magnesium alloys suffer from several limitations, including excessively rapid degradation, an imbalance between strength and toughness, and insufficient antibacterial properties. These drawbacks substantially hinder their clinical translation and large-scale application. To address these challenges and following the low-alloying design principle, an extruded Mg–Ag–In alloy was developed. This study focuses on a low-alloyed Mg–1Ag–0.5In composition with intrinsic antibacterial properties. The investigation examines its microstructural characteristics, mechanical performance, corrosion behavior, osteoblast compatibility, and antibacterial activity. The results showed that the extruded Mg–1Ag–0.5In alloy exhibited a favorable balance between strength and ductility. This synergy was primarily attributed to the coordinated deformation of tensile twins and multiple slip systems. During corrosion, the alloy transitioned from an initial mixed pitting and filamentous corrosion mode to a uniform filamentous corrosion pattern, which reduced the overall corrosion rate and facilitated the formation of a denser corrosion product layer. The corrosion driving force was mainly influenced by the grain orientation and the distribution of regions with high kernel average misorientation values. Furthermore, the extruded Mg–1Ag–0.5In alloy demonstrated excellent osteoblast compatibility, effectively promoting the proliferation of mouse embryonic osteoblast (MC3T3-E1) cells, and exhibited remarkable antibacterial activity.