Cu对Ni-Ti合金抗支架内再狭窄与耐蚀性能的影响
收稿日期: 2022-10-31
修回日期: 2022-12-07
网络出版日期: 2023-01-16
基金资助
国家重点研发计划项目(2022YFC2406003);国家自然科学基金项目(81873918);国家自然科学基金项目(82272099);辽宁省自然科学基金计划项目(2021020399-JH2/103);辽宁省自然科学基金计划项目(2022-YGJC-34)
Effect of Cu on In-Stent Restenosis and Corrosion Resistance of Ni-Ti Alloy
Received date: 2022-10-31
Revised date: 2022-12-07
Online published: 2023-01-16
Supported by
National Key Research and Development Program of China(2022YFC2406003);National Natural Science Foundation of China(81873918);National Natural Science Foundation of China(82272099);Natural Science Foundation of Liaoning Province(2021020399-JH2/103);Natural Science Foundation of Liaoning Province(2022-YGJC-34)
基于合金化策略，通过向医用Ni-Ti合金中添加适量Cu制备生物功能化Ni-Ti-Cu合金，并利用OM、SEM、XRD、表面自由能测试、电化学实验以及体外细胞实验等方法，探究Ni-Ti-Cu合金抑制支架内再狭窄作用以及耐蚀性能。结果表明，与Ni-Ti合金相比，Ni-Ti-Cu合金由等轴奥氏体组织向细板条马氏体组织转变，其表面自由能显著降低，在模拟人体血液中的耐蚀性能提高。此外，Ni-Ti-Cu合金浸提液还可显著促进人脐静脉内皮细胞的增殖、迁移及成血管能力。与Ni-Ti合金相比，Ni-Ti-Cu合金可降低血液凝固速率，表现出更优异的抗凝血性能，具有抑制支架内再狭窄发生的应用潜力。
许林杰 , 刘徽 , 任玲 , 杨柯 . Cu对Ni-Ti合金抗支架内再狭窄与耐蚀性能的影响[J]. 金属学报, 2023 , 59(4) : 577 -584 . DOI: 10.11900/0412.1961.2022.00553
Ni-Ti alloys are used widely as a self-expanding vascular stent material because of their unique shape memory effect and superelasticity. However, after implantation, there is a risk of in-stent restenosis (ISR) because of insufficient endothelialization and coagulation problems. As a biological functional metal element, the proper addition of Cu endows vascular stent materials, such as stainless steel and cobalt-based alloys, with significant endothelialization promotion and anticoagulant effect, which can effectively inhibit the occurrence of ISR. Based on the alloying strategy, a biofunctional Ni-Ti-Cu alloy was prepared by adding the proper amount of Cu into medical Ni-Ti alloys. The inhibition effect of ISR and corrosion resistance of the Ni-Ti-Cu alloy were studied via OM, SEM, XRD, surface free energy test, electrochemical test, and in vitro cell experiment. Results showed that compared with the Ni-Ti alloy, the Ni-Ti-Cu alloy promoted the transformation of an equiaxed austenite grain structure to fine lath martensite, reduced the surface free energy, and improved corrosion resistance in simulated human blood. In addition, the extract of the Ni-Ti-Cu alloy could promote the proliferation, migration, and tube formation of human umbilical vein endothelial cells. Furthermore, compared with the Ni-Ti alloy, the Ni-Ti-Cu alloy decreased the blood coagulation rate, presenting better anticoagulation ability, which has an application potential for inhibiting the occurrence of ISR.
Key words： Ni-Ti alloy; Cu; in-stent restenosis; corrosion resistance
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