综述

3D打印医用钛合金多孔材料力学性能研究进展

  • 李述军 ,
  • 侯文韬 ,
  • 郝玉琳 ,
  • 杨锐
展开
  • 中国科学院金属研究所 师昌绪先进材料创新中心 沈阳 110016
李述军,男,1975年生,研究员,博士
李述军,shjli@imr.ac.cn,主要从事医用钛合金及其增材制造研究;杨 锐,ryang@imr.ac.cn,主要从事先进钛合金及钛基复合材料研究

收稿日期: 2022-11-03

  修回日期: 2022-11-29

  网络出版日期: 2022-12-22

基金资助

国家自然科学基金项目(51871220);国家自然科学基金项目(U2241245);中国科学院前沿科学重点研究项目(QYZDJ-SSW-JSC031)

Research Progress on the Mechanical Properties of the Biomedical Titanium Alloy Porous Structures Fabricated by 3D Printing Technique

  • LI Shujun ,
  • HOU Wentao ,
  • HAO Yulin ,
  • YANG Rui
Expand
  • Shi -changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China
LI Shujun, professor, Tel: (024)83978841, E-mail: shjli@imr.ac.cn;YANG Rui, professor, Tel: (024)23971512, E-mail: ryang@imr.ac.cn

Received date: 2022-11-03

  Revised date: 2022-11-29

  Online published: 2022-12-22

Supported by

National Natural Science Foundation of China(51871220);National Natural Science Foundation of China(U2241245);Key Research Program of Frontier Sciences, Chinese Academy of Sciences(QYZDJ-SSW-JSC031)

摘要

钛合金多孔材料具有与人体骨匹配的弹性模量,可有效解决金属植入物与人体骨弹性错配;其内部存在的大量孔隙有利于周围细胞的长入和新骨的生长,从而促进骨组织形成。近年来,增材制造(3D打印)技术被用于钛合金多孔材料制备,该方法可以精确控制孔隙参数,并且克服了因金属高熔点造成的制备困难。本文综述了作者团队在3D打印医用Ti-6Al-4V、纯Ti以及低模量钛合金多孔材料组织及力学性能的研究结果。对于Ti-6Al-4V两相合金,其疲劳性能受多孔结构设计和多种后处理的影响。纯Ti多孔材料较Ti-6Al-4V更优的疲劳寿命源于其更好的塑性和形变孪晶的应变硬化效应。低模量Ti2448合金的优异疲劳寿命则源于其超弹性提高裂纹萌生寿命,高韧性提高裂纹扩展寿命。最后展望了复杂生理环境腐蚀疲劳性能、多孔材料表面生物活化处理和新型医用金属体系多孔材料等发展方向。

本文引用格式

李述军 , 侯文韬 , 郝玉琳 , 杨锐 . 3D打印医用钛合金多孔材料力学性能研究进展[J]. 金属学报, 2023 , 59(4) : 478 -488 . DOI: 10.11900/0412.1961.2022.00566

Abstract

Porous titanium alloys have been used for biomedical implants owing to their low-modulus matching with that of human bones and interconnecting pores with suitable size, which facilitates bone in-growth and satisfies the requirement of a successful implant. Recently, additive manufacturing (3D printing) has emerged as an excellent technology for manufacturing porous implants with accurate designed pore parameters and overcoming processing difficulties caused by high melting temperatures of metals. In this paper, the microstructure and mechanical properties of porous Ti-6Al-4V, commercial pure titanium (CP-Ti), and low-modulus Ti2448 alloys produced by 3D printing, obtained mainly by the authors' group, are reviewed. For Ti-6Al-4V, its fatigue properties are affected by the type of mesh struts and post processing. The better fatigue life of CP-Ti compared to that of Ti-6Al-4V derives from its superior ductility and the strain hardening effect caused by deformation twins. The excellent fatigue life of the low-modulus Ti2448 alloy results from its superelasticity and the high toughness, which increases the crack nucleation life and fatigue crack propagation life, respectively. Future directions of corrosion-fatigue properties of materials in complex physiological environments, surface biological functionalization, and porous material of new metallic alloy systems are discussed.

参考文献

1 Gibson L J. Cellular solids [J]. MRS Bull., 2003, 28: 270
2 Head W C, Bauk D J, Emerson Jr R H. Titanium as the material of choice for cementless femoral components in total hip arthroplasty [J]. Clin. Orthop. Relat. Res., 1995, (311): 85
3 Krishna B V, Bose S, Bandyopadhyay A. Low stiffness porous Ti structures for load-bearing implants [J]. Acta Biomater., 2007, 3: 997
4 Niinomi M. Mechanical biocompatibilities of titanium alloys for biomedical applications [J]. J. Mech. Behav. Biomed. Mater., 2008, 1: 30
5 Nune K C, Misra R D K, Gaytan S M, et al. Biological response of next-generation of 3D Ti-6Al-4V biomedical devices using additive manufacturing of cellular and functional mesh structures [J]. J. Biomater. Tiss. Eng., 2014, 4: 755
6 Banhart J. Manufacture, characterisation and application of cellular metals and metal foams [J]. Prog. Mater. Sci., 2001, 46: 559
7 Zhang L C, Liu Y J, Li S J, et al. Additive manufacturing of titanium alloys by electron beam melting: A review [J]. Adv. Eng. Mater., 2018, 20: 1700842
8 Murr L E. Frontiers of 3D printing/additive manufacturing: From human organs to aircraft fabrication [J]. J. Mater. Sci. Technol., 2016, 32: 987
9 Narra S P, Cunningham R, Beuth J, et al. Location specific solidification microstructure control in electron beam melting of Ti-6Al-4V [J]. Addit. Manufact., 2018, 19: 160
10 Xu W, Lui E W, Pateras A, et al. In situ tailoring microstructure in additively manufactured Ti-6Al-4V for superior mechanical performance [J]. Acta Mater., 2017, 125: 390
11 Cheng X Y, Li S J, Murr L E, et al. Compression deformation behavior of Ti-6Al-4V alloy with cellular structures fabricated by electron beam melting [J]. J. Mech. Behav. Biomed. Mater., 2012, 16: 153
12 Murr L E, Gaytan S M, Medina F, et al. Next-generation biomedical implants using additive manufacturing of complex, cellular and functional mesh arrays [J]. Philos. Trans. Roy. Soc., 2010, 368A: 1999
13 Li S J, Xu Q S, Wang Z, et al. Influence of cell shape on mechanical properties of Ti-6Al-4V meshes fabricated by electron beam melting method [J]. Acta Biomater., 2014, 10: 4537
14 Murr L E, Amato K N, Li S J, et al. Microstructure and mechanical properties of open-cellular biomaterials prototypes for total knee replacement implants fabricated by electron beam melting [J]. J. Mech. Behav. Biomed. Mater., 2011, 4: 1396
15 Hernández-Nava E, Smith C J, Derguti F, et al. The effect of density and feature size on mechanical properties of isostructural metallic foams produced by additive manufacturing [J]. Acta Mater., 2015, 85: 387
16 Parthasarathy J, Starly B, Raman S, et al. Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM) [J]. J. Mech. Behav. Biomed. Mater., 2010, 3: 249
17 Evans A G, Hutchinson J W, Fleck N A, et al. The topological design of multifunctional cellular metals [J]. Prog. Mater. Sci., 2001, 46: 309
18 Hollister S J. Porous scaffold design for tissue engineering [J]. Nat. Mater., 2005, 4: 518
19 Li S J, Zhao S, Hou W T, et al. Functionally graded Ti-6Al-4V meshes with high strength and energy absorption [J]. Adv. Eng. Mater., 2016, 18: 34
20 Zhang S Z, Li C, Hou W T, et al. Longitudinal compression behavior of functionally graded Ti-6Al-4V meshes [J]. J. Mater. Sci. Technol., 2016, 32: 1098
21 Yuan W, Hou W T, Li S J, et al. Heat treatment enhancing the compressive fatigue properties of open-cellular Ti-6Al-4V alloy prototypes fabricated by electron beam melting [J]. J. Mater. Sci. Technol., 2018, 34: 1127
22 Li S J, Murr L E, Cheng X Y, et al. Compression fatigue behavior of Ti-6Al-4V mesh arrays fabricated by electron beam melting [J]. Acta Mater., 2012, 60: 793
23 Gibson L J, Ashby M F. Cellular Solids: Structure and Properties [M]. 2nd Ed., New York: Cambridge University Press, 1997: 453
24 Hedayati R, Hosseini-Toudeshky H, Sadighi M, et al. Computational prediction of the fatigue behavior of additively manufactured porous metallic biomaterials [J]. Int. J. Fatigue, 2016, 84: 67
25 Li K, Gao X L, Subhash G. Effects of cell shape and cell wall thickness variations on the elastic properties of two-dimensional cellular solids [J]. Int. J. Solids Struct., 2005, 42: 1777
26 Zhao S, Li S J, Hou W T, et al. The influence of cell morphology on the compressive fatigue behavior of Ti-6Al-4V meshes fabricated by electron beam melting [J]. J. Mech. Behav. Biomed. Mater., 2016, 59: 251
27 Zargarian A, Esfahanian M, Kadkhodapour J, et al. Numerical simulation of the fatigue behavior of additive manufactured titanium porous lattice structures [J]. Mater. Sci. Eng., 2016, C60: 339
28 Yavari S A, Ahmadi S M, Wauthle R, et al. Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials [J]. J. Mech. Behav. Biomed. Mater., 2015, 43: 91
29 Ahmadi S M, Hedayati R, Li Y, et al. Fatigue performance of additively manufactured meta-biomaterials: The effects of topology and material type [J]. Acta Biomater., 2018, 65: 292
30 Zhao S, Li S J, Wang S G, et al. Compressive and fatigue behavior of functionally graded Ti-6Al-4V meshes fabricated by electron beam melting [J]. Acta Mater., 2018, 150: 1
31 Wang Q S, Li S J, Hou W T, et al. Mechanistic understanding of compression-compression fatigue behavior of functionally graded Ti-6Al-4V mesh structure fabricated by electron beam melting [J]. J. Mech. Behav. Biomed. Mater., 2020, 103: 103590
32 Dai D H, Gu D D. Effect of metal vaporization behavior on keyhole-mode surface morphology of selective laser melted composites using different protective atmospheres [J]. Appl. Surf. Sci., 2015, 355: 310
33 Zhao X L, Li S J, Zhang M, et al. Comparison of the microstructures and mechanical properties of Ti-6Al-4V fabricated by selective laser melting and electron beam melting [J]. Mater. Des., 2016, 95: 21
34 Dallago M, Fontanari V, Torresani E, et al. Fatigue and biological properties of Ti-6Al-4V ELI cellular structures with variously arranged cubic cells made by selective laser melting [J]. J. Mech. Behav. Biomed. Mater., 2018, 78: 381
35 Pyka G, Burakowski A, Kerckhofs G, et al. Surface modification of Ti6Al4V open porous structures produced by additive manufacturing [J]. Adv. Eng. Mater., 2012, 14: 363
36 Liu Y J, Ren D C, Li S J, et al. Enhanced fatigue characteristics of a topology-optimized porous titanium structure produced by selective laser melting [J]. Addit. Manuf., 2020, 32: 101060
37 Hao Y L, Li S J, Sun S Y, et al. Elastic deformation behaviour of Ti-24Nb-4Zr-7.9Sn for biomedical applications [J]. Acta Biomater., 2007, 3: 277
38 Wang H L, Hao Y L, He S Y, et al. Elastically confined martensitic transformation at the nano-scale in a multifunctional titanium alloy [J]. Acta Mater., 2017, 135: 330
39 Wang W J, Gong D L, Wang H L, et al. Spinodal decomposition coupled with a continuous crystal ordering in a titanium alloy [J]. Acta Mater., 2022, 233: 117969
40 Liu Y J, Li S J, Wang H L, et al. Electron beam melted beta-type Ti-24Nb-4Zr-8Sn porous structures with high strength-to-modulus ratio [J]. J. Mater. Sci. Technol., 2016, 32: 505
41 Liu Y J, Li S J, Wang H L, et al. Microstructure, defects and mechanical behavior of beta-type titanium porous structures manufactured by electron beam melting and selective laser melting [J]. Acta Mater., 2016, 113: 56
42 Liu Y J, Wang H L, Li S J, et al. Compressive and fatigue behavior of beta-type titanium porous structures fabricated by electron beam melting [J]. Acta Mater., 2017, 126: 58
43 Yang H X, Li S J, Hou W T, et al. Recoverable strain in a new biomedical Ti-24Nb-4Zr-8Sn alloy with cellular structure fabricated by electron beam melting [J]. Mater. Technol., 2020, 35: 881
44 Bai Y, Gai X, Li S J, et al. Improved corrosion behaviour of electron beam melted Ti-6Al-4V alloy in phosphate buffered saline [J]. Corros. Sci., 2017, 123: 289
45 Gai X, Liu R, Bai Y, et al. Electrochemical behavior of open-cellular structured Ti-6Al-4V alloy fabricated by electron beam melting in simulated physiological fluid: The significance of pore characteristics [J]. J. Mater. Sci. Technol., 2022, 97: 272
46 Gai X, Bai Y, Li S J, et al. In-situ monitoring of the electrochemical behavior of cellular structured biomedical Ti-6Al-4V alloy fabricated by electron beam melting in simulated physiological fluid [J]. Acta Biomater., 2020, 106: 387
47 Gai X, Bai Y, Li S J, et al. In-situ monitoring of the electrochemical corrosion behavior in fluoride environment of cellular structured Ti6Al4V alloy fabricated by electron beam melting [J]. Corros. Sci., 2021, 181: 109258
48 Cao H J, Feng L F, Wu Z X, et al. Effect of low-intensity pulsed ultrasound on the biological behavior of osteoblasts on porous titanium alloy scaffolds: An in vitro and in vivo study [J]. Mater. Sci. Eng., 2017, C80: 7
49 Nune K C, Kumar A, Misra R D K, et al. Functional response of osteoblasts in functionally gradient titanium alloy mesh arrays processed by 3D additive manufacturing [J]. Colloids Surf., 2017, 150B: 78
50 Nune K C, Misra R D K, Li S J, et al. The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation [J]. J. Biomed. Mater. Res., 2016, 104A: 2488
文章导航

/