可降解锌合金血管支架的研究现状、面临的挑战与对策思考
收稿日期: 2020-05-13
修回日期: 2020-07-02
网络出版日期: 2020-08-28
基金资助
国家重点研发计划项目(2018YFE0115400);国家自然科学基金项目(51971134);上海交通大学多学科交叉项目培育(转化)项目(ZH2018ZDA34)
Research Status, Challenges, and Countermeasures of Biodegradable Zinc-Based Vascular Stents
Received date: 2020-05-13
Revised date: 2020-07-02
Online published: 2020-08-28
Supported by
National Key Research and Development Program of China(2018YFE0115400);National Natural Science Foundation of China(51971134);Interdisciplinary Project of Shanghai Jiao Tong University, China(ZH2018ZDA34)
金属Zn可在人体内降解吸收，其降解速率最适合血管支架的临床要求。同时Zn2+本身也是人体必要的营养元素，参与体内200多种酶的活动与代谢，并具有修复和提升血管内皮的完整性和抗动脉粥样硬化的功能，具有作为血管支架材料的天然优势。本文结合作者课题组近年的研究工作，对可降解锌合金血管支架领域的研究进行了系统总结，分别从可降解锌合金血管支架的研究背景、研究现状与挑战、解决这些挑战问题的思路和对策、以及未来发展展望等方面进行了介绍和评述，期待能对本领域的研究工作给予借鉴和启迪，从而对推动我国在相关领域的研究发展起到有益作用。
关键词： 可降解锌合金血管支架; 研究现状; 临床挑战; 对策思考
钱漪 , 袁广银 . 可降解锌合金血管支架的研究现状、面临的挑战与对策思考[J]. 金属学报, 2021 , 57(3) : 272 -282 . DOI: 10.11900/0412.1961.2020.00161
Human body can absorb and degrade Zn. Among the biodegradable metals of Mg, Zn, and Fe, the degradation rate of Zn is the most suitable for the clinical requirements of vascular stents. Zinc ion is an essential nutrient in human body; it participates in the metabolic activities of more than 200 enzymes. Zn promotes and maintains the integrity of vascular endothelium and inhibits the progress of artery atherosclerosis, making it naturally advantageous as a vascular stent material. This review systematically summarizes the research in the field of biodegradable zinc-based vascular stents based on recent studies conducted by the author's research team. In addition, this review introduces and discusses the research background, status, and challenges as well as the countermeasures of the challenges and prospects for the future development of biodegradable Zn-based vascular stents. It is expected that the comments and itemized strategies for solving the identified challenges in this review can inspire related researchers to perform research studies in associated fields in China.
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