纯Mo及钼基可降解金属材料的研究现状与发展趋势
收稿日期: 2025-10-20
修回日期: 2026-02-11
网络出版日期: 2026-03-24
基金资助
国家自然科学基金重点项目(52531008)
Research Status and Future Directions of Pure Mo and Mo-Based Biodegradable Metals
Received date: 2025-10-20
Revised date: 2026-02-11
Online published: 2026-03-24
Supported by
National Natural Science Foundation of China(52531008)
Mo是人体所必需的微量元素之一，金属纯Mo因其优异的力学性能、均匀的降解行为和良好的生物相容性，成为心脑血管支架、心脏起搏器、肠胃吻合钉和可穿戴生物电子器械等多种植/介入医疗器械潜在的候选材料。钼基金属材料已有一些合金体系和复合材料应用于航空航天、电子和化工等领域，但作为可降解金属用于医疗领域的研究尚处于起步阶段，诸多关键科学问题尚未厘清。本文聚焦纯Mo及钼基金属材料的材料本性，借鉴其在工程领域的制造路径和性能优势，梳理其在生理环境中的腐蚀行为和降解产物的潜在生物学效应，基于材料生物降解性和生物相容性的双重筛选原则，并结合可降解金属器械的服役需求，提出新型钼基可降解金属材料的合金成分设计、微观组织、塑性变形、增材制造和生物医学性能提升策略，展望其未来可能在生物医学领域的应用前景及发展方向。
郑玉峰 , 谌雨农 . 纯Mo及钼基可降解金属材料的研究现状与发展趋势[J]. 金属学报, 2026 , 62(5) : 905 -922 . DOI: 10.11900/0412.1961.2025.00323
Mo, a trace element in the human body, has attracted increasing attention owing to its excellent mechanical properties, uniform degradation behavior, and favorable biocompatibility. The highlighted features make it a promising candidate for various biodegradable medical devices, including cardiovascular and neurovascular stents, cardiac pacemakers, gastrointestinal anastomotic staples, and wearable bioelectronic devices. Currently, Mo and its alloys have been developed as industrial materials and are well-established in aerospace, electronics, and chemical engineering. However, research on Mo and its alloys as biomaterials is an emerging field of study and faces several critical scientific challenges. In this review, we highlight Mo's intrinsic material characteristics, summarize traditional manufacturing methods and performance advantages, and outline its degradation mechanisms and biological responses in physiological environments. Furthermore, we propose design strategies for Mo-based biodegradable metals that consider biodegradability, biocompatibility, and the functional requirements of biodegradable implants, focusing on composition, microstructure, plastic deformation, and additive manufacturing. Finally, we discuss the future applications and developmental directions of Mo-based biodegradable metals in the field of biomaterials.
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