可降解镁基复合材料的制备及其在骨科领域的研究进展
收稿日期: 2024-10-29
修回日期: 2025-01-13
网络出版日期: 2025-02-13
基金资助
国家杰出青年科学基金项目(52225101);国家自然科学基金项目(52301132);中央高校基本科研业务费项目(2023CDJYXTD-002)
Preparation of Biodegradable Mg-Based Composites and Their Recent Advances in Orthopedic Applications
Received date: 2024-10-29
Revised date: 2025-01-13
Online published: 2025-02-13
Supported by
National Funds for Distinguished Young Scholars(52225101);National Natural Science Foundation of China(52301132);Fundamental Research Funds for the Central Universities(2023CDJYXTD-002)
欧阳思慧 , 佘加 , 陈先华 , 潘复生 . 可降解镁基复合材料的制备及其在骨科领域的研究进展[J]. 金属学报, 2025 , 61(3) : 455 -474 . DOI: 10.11900/0412.1961.2024.00362
Biodegradable Mg-based materials have emerged as a promising class of orthopedic implants in the 21st century, owing to their excellent osteogenic properties and an elastic modulus similar to that of cortical bone. This review summarizes the current applications and development trends of Mgbased composites in bone repair. First, the fabrication methods of Mg-based composites, along with their advantages and disadvantages, are discussed. Second, the impact of reinforcement on the mechanical properties and degradation behavior of these composites is examined. Third, preclinical studies on the use of Mg-based composites in fracture fixation and bone defect repair are reviewed, confirming their bioactivity and clinical safety. Fourth, the effects of the degradation behavior of Mg-based composites on stem cell osteogenic differentiation and the related molecular mechanisms are explored. Finally, the challenges of applying Mg-based composites for bone repair based on existing preclinical studies are outlined, and potential future advancements are proposed.
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