可降解Zn表面金属-多酚载药涂层骨生成和抗菌性能
收稿日期: 2023-02-02
修回日期: 2023-03-31
网络出版日期: 2023-04-13
基金资助
国家重点研发计划项目(2016YFC1102500);四川省科技计划项目(2020YFH0077);四川省科技计划项目(2024YFHZ0310);材料腐蚀与防护四川省重点实验室开放基金项目(2022CL07)
Osteogenic and Antibacterial Metal-Polyphenol Drug-Loaded Coating on Biodegradable Zinc for Orthopedic Implants Application
Received date: 2023-02-02
Revised date: 2023-03-31
Online published: 2023-04-13
Supported by
National Key Research and Development Program of China(2016YFC1102500);Science and Tech-nology Program of Sichuan Province(2020YFH0077);Science and Tech-nology Program of Sichuan Province(2024YFHZ0310);Open Fund Project of Sichuan Provincial Key Laboratory for Material Corrosion and Protection(2022CL07)
Zn及其合金因其适中的降解速率和潜在的生物功能性在骨植入体领域展现出广泛的应用前景。然而，其降解过程中存在Zn2+释放过快导致促骨生成能力不足、不均匀腐蚀造成力学性能失效以及较差的抗菌性能等问题，限制了其应用。本工作采用交替沉积法，利用活性金属离子与单宁酸螯合并负载二甲双胍在Zn表面制备金属-多酚载药功能涂层。结果表明，该涂层结构致密，提高了Zn基底的抗腐蚀能力，改善了腐蚀降解模式，延缓Zn2+释放并调控二甲双胍的释放；体外前成骨细胞(MC3T3-E1)培养证实该涂层具有优异的促骨生成能力；抗菌实验结果表明该涂层具有优异的抗菌效果。
林雪 , 钱军余 , 张文泰 , 王鹏 , 万国江 . 可降解Zn表面金属-多酚载药涂层骨生成和抗菌性能[J]. 金属学报, 2024 , 60(11) : 1545 -1558 . DOI: 10.11900/0412.1961.2023.00035
Biodegradable metallic Zn materials are being considered for orthopedic implant applications because of their moderate degradation rate and potential bio-functionalities. Nevertheless, their clinical use is limited due to inadequate osteogenic properties owing to Zn2+ burst release, premature mechanical failure caused by non-uniform corrosion, and poor antibacterial ability. Therefore, to overcome these issues, a metal-polyphenol drug-loaded coating was functionalized on the surface using an alternating chemical deposition method out of tannic acid/metformin molecules and active metallic ions via coordination/chelation reactions. The coating was characterized by homogeneous compactness, which enhanced the corrosion resistance of the Zn substrate, adjusted the corrosion mode, suppressed the release of Zn2+, and regulated metformin release. The in vitro pre-osteoblasts (MC3T3-E1) culture results showed that the coated Zn samples exhibited excellent osteogenic ability. The antibacterial assays with coated Zn samples demonstrated strong antibacterial efficiency.
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