医用可降解锌合金的生物相容性评价研究进展
收稿日期: 2022-09-23
修回日期: 2022-10-25
网络出版日期: 2023-01-09
基金资助
国家自然科学基金项目(51871020);国家重点研发计划项目(2016YFC1102500)
Research Progress on Biocompatibility Evaluation of Biomedical Degradable Zinc Alloys
Received date: 2022-09-23
Revised date: 2022-10-25
Online published: 2023-01-09
Supported by
National Natural Science Foundation of China(51871020);National Key Research and Development Program of China(2016YFC1102500)
锌合金由于其适宜的腐蚀速率、良好的力学性能，成为继镁合金与铁合金后的一种新型的可降解生物医用金属材料。近年来，研究者对锌合金的设计、加工制备以及降解机理进行了大量研究，但对其体内外生物相容性的研究尚不充分，仅评估了体外细胞毒性、溶血、凝血，少数材料植入动物体内进行了组织相容性的表征。然而生物相容性涉及细胞、组织、血液、免疫等复杂的局部反应和全身反应，除了材料本身的物理化学性质，还受到材料与机体相互作用的影响。本文分析了可降解医用锌合金的化学成分和物相组成，阐明了对其进行生物学评价的方法，并结合锌合金生物相容性研究现状，阐述未来的研究方向。
王鲁宁 , 尹玉霞 , 石章智 , 韩倩倩 . 医用可降解锌合金的生物相容性评价研究进展[J]. 金属学报, 2023 , 59(3) : 319 -334 . DOI: 10.11900/0412.1961.2022.00471
Zn and its alloys have recently been used as a new class of biodegradable biomedical metals besides magnesium and iron alloys, owing to their moderate corrosion rate and good mechanical properties. In recent years, researchers have rigorously studied the design, processing, and degradation mechanism of Zn alloys, but their biocompatibility has not been well explored. Past research on the biocompatibility of Zn alloys focused on in vitro cytotoxicity, hemolysis, and coagulation, and only a few materials were implanted into animals for characterizing the histocompatibility. Biocompatibility involves complex local and systemic reactions, such as cells, tissues, blood, and immunity. In addition to the physical and chemical properties of the material, the biocompatibility is also affected by interactions between the material and body. In this paper, the chemical and phase compositions of degradable zinc alloys were analyzed, and the biological evaluation methods were clarified. In view of the recent studies on zinc alloy biocompatibility, future research directions were proposed.
Key words： zinc alloy; biocompatibility; cytotoxicity; blood compatibility
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