综述

Ti及钛合金表面改性在生物医用领域的研究进展

  • 崔振铎 ,
  • 朱家民 ,
  • 姜辉 ,
  • 吴水林 ,
  • 朱胜利
展开
  • 天津大学 材料科学与工程学院 天津 300350
崔振铎,男,1962年生,教授,博士

收稿日期: 2022-03-30

  修回日期: 2022-05-09

  网络出版日期: 2022-05-16

基金资助

国家自然科学基金项目(51771131);国家自然科学基金项目(52173182)

Research Progress of the Surface Modification of Titanium and Titanium Alloys for Biomedical Application

  • Zhenduo CUI ,
  • Jiamin ZHU ,
  • Hui JIANG ,
  • Shuilin WU ,
  • Shengli ZHU
Expand
  • School of Materials Science and Engineering, Tianjin University, Tianjin 300350, China
ZHU Shengli, professor, Tel: 18920951755, E-mail: slzhu@tju.edu.cn

Received date: 2022-03-30

  Revised date: 2022-05-09

  Online published: 2022-05-16

Supported by

National Natural Science Foundation of China(51771131);National Natural Science Foundation of China(52173182)

摘要

Ti及钛合金作为人体硬组织的主要替代物之一,在生物医用领域应用广泛。为了更好地满足Ti及钛合金在人体中植入后的安全、舒适、耐久等需求,Ti及钛合金表面改性处理成为了研究的热点。本文基于Ti及钛合金的基础性能和存在的问题,从表面改性提高其力学性能、生物相容性、抑菌/抗菌性能等方面综述了Ti及钛合金表面改性在生物医用领域的研究进展,并提出了面临的挑战以及发展方向的建议。

本文引用格式

崔振铎 , 朱家民 , 姜辉 , 吴水林 , 朱胜利 . Ti及钛合金表面改性在生物医用领域的研究进展[J]. 金属学报, 2022 , 58(7) : 837 -856 . DOI: 10.11900/0412.1961.2022.00150

Abstract

Titanium and titanium alloys have widely been used in biomedical applications as main substitutes for hard human tissues. To better meet the needs of safety, comfort, and durability of titanium and titanium alloys after implantation in the human body, the surface modification treatment of titanium and titanium alloys has become a research hotspot. In this review, based on the basic properties and existing problems of titanium and titanium alloys, the methods of surface modification for titanium and titanium alloys are introduced to improve their mechanical properties, biocompatibility, and bacteriostatic/antibacterial properties. Furthermore, the current challenges and prospects have been presented in this paper.

参考文献

1 Geetha M, Singh A K, Asokamani R, et al. Ti based biomaterials, the ultimate choice for orthopaedic implants—A review [J]. Prog. Mater. Sci., 2009, 54: 397
2 Long M, Rack H J. Titanium alloys in total joint replacement—A materials science perspective [J]. Biomaterials, 1998, 19: 1621
3 Elias C N, Lima J H C, Valiev R, et al. Biomedical applications of titanium and its alloys [J]. JOM, 2008, 60(3): 46
4 Fonseca-García A, Pérez-Alvarez J, Barrera C C, et al. The effect of simulated inflammatory conditions on the surface properties of titanium and stainless steel and their importance as biomaterials [J]. Mater. Sci. Eng., 2016, C66: 119
5 Barceloux D G. Chromium [J]. J. Toxicol.: Clin. Toxicol., 1999, 37: 173
6 Nickens K P, Patierno S R, Ceryak S. Chromium genotoxicity: A double-edged sword [J]. Chem. Biol. Interact., 2010, 188: 276
7 Paustenbach D J, Tvermoes B E, Unice K M, et al. A review of the health hazards posed by cobalt [J]. Crit. Rev. Toxicol., 2013, 43: 316
8 Pavesi T, Moreira J C. Mechanisms and individuality in chromium toxicity in humans [J]. J. Appl. Toxicol., 2020, 40: 1183
9 Kaur M, Singh K. Review on titanium and titanium based alloys as biomaterials for orthopaedic applications [J]. Mater. Sci. Eng., 2019, C102: 844
10 Chen L Y, Cui Y W, Zhang L C. Recent development in beta titanium alloys for biomedical applications [J]. Metals, 2020, 10: 1139
11 Niinomi M, Liu Y, Nakai M, et al. Biomedical titanium alloys with Young's moduli close to that of cortical bone [J]. Regen. Biomater., 2016, 3: 173
12 Wang L Q, Lu W J, Qin J N, et al. Effect of precipitation phase on microstructure and superelasticity of cold-rolled beta titanium alloy during heat treatment [J]. Mater. Des., 2009, 30: 3873
13 Wang L Q, Xie L C, Lv Y T, et al. Microstructure evolution and superelastic behavior in Ti-35Nb-2Ta-3Zr alloy processed by friction stir processing [J]. Acta Mater., 2017, 131: 499
14 Gode C, Attarilar S, Eghbali B, et al. Electrochemical behavior of equal channel angular pressed titanium for biomedical application [C]. AIP Conf. Proc., 2015, 1653: 020041
15 Apaza-Bedoya K, Tarce M, Benfatti C A M, et al. Synergistic interactions between corrosion and wear at titanium-based dental implant connections: A scoping review [J]. J. Periodontal Res., 2017, 52: 946
16 Goldberg J R, Gilbert J L, Jacobs J J, et al. A multicenter retrieval study of the taper interfaces of modular hip prostheses [J]. Clin. Orthop. Relat. Res., 2002, 401: 149
17 Takai S, Yoshino N, Kusaka Y, et al. Dissemination of metals from a failed patellar component made of titanium-base alloy [J]. J. Arthroplasty, 2003, 18: 931
18 Moretti B, Pesce V, Maccagnano G, et al. Peripheral neuropathy after hip replacement failure: Is vanadium the culprit? [J]. Lancet, 2012, 379: 1676
19 Gilbert J L, Mali S, Urban R M, et al. In vivo oxide-induced stress corrosion cracking of Ti-6Al-4V in a neck-stem modular taper: Emergent behavior in a new mechanism of in vivo corrosion [J]. J. Biomed. Mater. Res., 2012, 100B: 584
20 Tsaryk R, Peters K, Barth S, et al. The role of oxidative stress in pro-inflammatory activation of human endothelial cells on Ti6Al4V alloy [J]. Biomaterials, 2013, 34: 8075
21 Mouthuy P A, Snelling S J B, Dakin S G, et al. Biocompatibility of implantable materials: An oxidative stress viewpoint [J]. Biomaterials, 2016, 109: 55
22 Kasai Y, Iida R, Uchida A. Metal concentrations in the serum and hair of patients with titanium alloy spinal implants [J]. Spine, 2003, 28: 1320
23 Verstraeten S V, Aimo L, Oteiza P I. Aluminium and lead: Molecular mechanisms of brain toxicity [J]. Arch. Toxicol., 2008, 82: 789
24 Jafari M S, Coyle C, Mortazavi J S M, et al. Revision hip arthroplasty: Infection is the most common cause of failure [J]. Clin. Orthop. Relat. Res., 2010, 468: 2046
25 Le D H, Goodman S B, Maloney W J, et al. Current modes of failure in TKA: Infection, instability, and stiffness predominate [J]. Clin. Orthop. Relat. Res., 2014, 472: 2197
26 Chouirfa H, Bouloussa H, Migonney V, et al. Review of titanium surface modification techniques and coatings for antibacterial applications [J]. Acta Biomater., 2019, 83: 37
27 Maher S, Mazinani A, Barati M R, et al. Engineered titanium implants for localized drug delivery: Recent advances and perspectives of titania nanotubes arrays [J]. Expert Opin. Drug Deliv., 2018, 15: 1021
28 Correa D R N, Kuroda P A B, Lourenço M L, et al. Development of Ti-15Zr-Mo alloys for applying as implantable biomedical devices [J]. J. Alloys Compd., 2018, 749: 163
29 Bai Y J, Deng Y, Zheng Y F, et al. Characterization, corrosion behavior, cellular response and in vivo bone tissue compatibility of titanium-niobium alloy with low Young's modulus [J]. Mater. Sci. Eng., 2016, C59: 565
30 Ou K L, Weng C C, Lin Y H, et al. A promising of alloying modified beta-type titanium-niobium implant for biomedical applications: Microstructural characteristics, in vitro biocompatibility and antibacterial performance [J]. J. Alloys Compd., 2017, 697: 231
31 Zhou Y, Li Y X, Yang X J, et al. Influence of Zr content on phase transformation, microstructure and mechanical properties of Ti75 - x Nb25Zr x (x = 0-6) alloys [J]. J. Alloys Compd., 2009, 486: 628
32 Qiu K J, Liu Y, Zhou F Y, et al. Microstructure, mechanical properties, castability and in vitro biocompatibility of Ti-Bi alloys developed for dental applications [J]. Acta Biomater., 2015, 15: 254
33 Ahn H, Lee D, Lee K M, et al. Oxidation behavior and corrosion resistance of Ti-10Ta-10Nb alloy [J]. Surf. Coat. Technol., 2008, 202: 5784
34 Nune K C, Misra R D K, Li S J, et al. Osteoblast cellular activity on low elastic modulus Ti-24Nb-4Zr-8Sn alloy [J]. Dent. Mater., 2017, 33: 152
35 Zheng Y F, Zhang B B, Wang B L, et al. Introduction of antibacterial function into biomedical TiNi shape memory alloy by the addition of element Ag [J]. Acta Biomater., 2011, 7: 2758
36 Li H B, Cui Z D, Li Z Y, et al. Effect of gas nitriding treatment on cavitation erosion behavior of commercially pure Ti and Ti-6Al-4V alloy [J]. Surf. Coat. Technol., 2013, 221: 29
37 Li H B, Cui Z D, Li Z Y, et al. Microstructure and cavitation erosion properties of ceramic coatings fabricated on Ti-6Al-4V alloy by pack carburizing [J]. J. Mater. Eng. Perform., 2014, 23: 2772
38 Zhu Y H, Wang W, Jia X Y, et al. Deposition of TiC film on titanium for abrasion resistant implant material by ion-enhanced triode plasma CVD [J]. Appl. Surf. Sci., 2012, 262: 156
39 Li Q, Niinomi M, Nakai M, et al. Improvements in the superelasticity and change in deformation mode of β-type TiNb24Zr2 alloys caused by aging treatments [J]. Metall. Mater. Trans., 2011, 42A: 2843
40 Liu Y, Li K Y, Luo T, et al. Powder metallurgical low-modulus Ti-Mg alloys for biomedical applications [J]. Mater. Sci. Eng., 2015, C56: 241
41 Karre R, Kodli B K, Rajendran A, et al. Comparative study on Ti-Nb binary alloys fabricated through spark plasma sintering and conventional P/M routes for biomedical application [J]. Mater. Sci. Eng., 2019, C94: 619
42 Attar H, Calin M, Zhang L C, et al. Manufacture by selective laser melting and mechanical behavior of commercially pure titanium [J]. Mater. Sci. Eng., 2014, A593: 170
43 Li X P, Van Humbeeck J, Kruth J P. Selective laser melting of weak-textured commercially pure titanium with high strength and ductility: A study from laser power perspective [J]. Mater. Des., 2017, 116: 352
44 García I, De Damborenea J J. Corrosion properties of tin prepared by laser gas alloying of Ti and Ti6Al4V [J]. Corros. Sci., 1998, 40: 1411
45 Jiang P, He X L, Li X X, et al. Wear resistance of a laser surface alloyed Ti-6Al-4V alloy [J]. Surf. Coat. Technol., 2000, 130: 24
46 Yue T M, Yu J K, Mei Z, et al. Excimer laser surface treatment of Ti-6Al-4V alloy for corrosion resistance enhancement [J]. Mater. Lett., 2002, 52: 206
47 Hays S J. Therapeutic approaches to the treatment of neuroinflammatory diseases [J]. Curr. Pharm. Des., 1998, 4: 335
48 Wang D, He G, Tian Y, et al. Dual effects of acid etching on cell responses and mechanical properties of porous titanium with controllable open-porous structure [J]. J. Biomed. Mater. Res., 2020, 108B: 2386
49 Szmukler-Moncler S, Perrin D, Ahossi V, et al. Biological properties of acid etched titanium implants: Effect of sandblasting on bone anchorage [J]. J. Biomed. Mater. Res., 2004, 68B: 149
50 Baleani M, Viceconti M, Toni A. The effect of sandblasting treatment on endurance properties of titanium alloy hip prostheses [J]. Artif. Organs, 2000, 24: 296
51 Szmukler-Moncler S, Testori T, Bernard J P. Etched implants: A comparative surface analysis of four implant systems [J]. J. Biomed. Mater. Res., 2004, 69B: 46
52 Wennerberg A, Albrektsson T. Effects of titanium surface topography on bone integration: A systematic review [J]. Clin. Oral Implants Res., 2009, 20: 172
53 Klokkevold P R, Johnson P, Dadgostari S, et al. Early endosseous integration enhanced by dual acid etching of titanium: A torque removal study in the rabbit [J]. Clin. Oral Implants Res., 2001, 12: 350
54 Ferraris S, Venturello A, Miola M, et al. Antibacterial and bioactive nanostructured titanium surfaces for bone integration [J]. Appl. Surf. Sci., 2014, 311: 279
55 Li J, Zhou P, Attarilar S, et al. Innovative surface modification procedures to achieve micro/nano-graded Ti-based biomedical alloys and implants [J]. Coatings, 2021, 11: 647
56 Chiang H J, Hsu H J, Peng P W, et al. Early bone response to machined, sandblasting acid etching (SLA) and novel surface-functionalization (SLAffinity) titanium implants: Characterization, biomechanical analysis and histological evaluation in pigs [J]. J. Biomed. Mater. Res., 2016, 104A: 397
57 Gupta N, Santhiya D, Murugavel S, et al. Effects of transition metal ion dopants (Ag, Cu and Fe) on the structural, mechanical and antibacterial properties of bioactive glass [J]. Colloids Surf., 2018, 538A: 393
58 Attarilar S, Ebrahimi M, Djavanroodi F, et al. 3D printing technologies in metallic implants: A thematic review on the techniques and procedures [J]. Int. J. Bioprint., 2021, 7: 306
59 Kurella A, Dahotre N B. Review paper: Surface modification for bioimplants: The role of laser surface engineering [J]. J. Biomater. Appl., 2005, 20: 5
60 Tiainen L, Abreu P, Buciumeanu M, et al. Novel laser surface texturing for improved primary stability of titanium implants [J]. J. Mech. Behav. Biomed. Mater., 2019, 98: 26
61 Cunha A, Elie A M, Plawinski L, et al. Femtosecond laser surface texturing of titanium as a method to reduce the adhesion of Staphylococcus aureus and biofilm formation [J]. Appl. Surf. Sci., 2016, 360: 485
62 Lee B H, Kim J K, Kim Y D, et al. In vivo behavior and mechanical stability of surface-modified titanium implants by plasma spray coating and chemical treatments [J]. J. Biomed. Mater. Res., 2004, 69A: 279
63 Sargin F, Erdogan G, Kanbur K, et al. Investigation of in vitro behavior of plasma sprayed Ti, TiO2 and HA coatings on peek [J]. Surf. Coat. Technol., 2021, 411: 126965
64 Khor K A, Gu Y W, Quek C H, et al. Plasma spraying of functionally graded hydroxyapatite/Ti-6Al-4V coatings [J]. Surf. Coat. Technol., 2003, 168: 195
65 Hameed P, Gopal V, Bjorklund S, et al. Axial suspension plasma spraying: An ultimate technique to tailor Ti6Al4V surface with hap for orthopaedic applications [J]. Colloids Surf., 2019, 173B: 806
66 Singh H, Prakash C, Singh S. Plasma spray deposition of HA-TiO2 on β-phase Ti-35Nb-7Ta-5Zr alloy for hip stem: Characterization of bio-mechanical properties, wettability, and wear resistance [J]. J. Bionic Eng., 2020, 17: 1029
67 Duta L. In vivo assessment of synthetic and biological-derived calcium phosphate-based coatings fabricated by pulsed laser deposition: A review [J]. Coatings, 2021, 11: 99
68 Galindo-Valdés J S, Cortés-Hernández D A, Ortiz-Cuellar J C, et al. Laser deposition of bioactive coatings by in situ synthesis of pseudowollastonite on Ti6Al4V alloy [J]. Opt. Laser Technol., 2021, 134: 106586
69 Cao J X, Lian R Z, Jiang X H. Magnesium and fluoride doped hydroxyapatite coatings grown by pulsed laser deposition for promoting titanium implant cytocompatibility [J]. Appl. Surf. Sci., 2020, 515: 146069
70 Zaveri N, Mahapatra M, Deceuster A, et al. Corrosion resistance of pulsed laser-treated Ti-6Al-4V implant in simulated biofluids [J]. Electrochim. Acta, 2008, 53: 5022
71 Chen L Y, Komasa S, Hashimoto Y, et al. In vitro and in vivo osteogenic activity of titanium implants coated by pulsed laser deposition with a thin film of fluoridated hydroxyapatite [J]. Int. J. Mol. Sci., 2018, 19: 1127
72 Pelletier H, Nelea V, Mille P, et al. Mechanical properties of pulsed laser-deposited hydroxyapatite thin film implanted at high energy with N+ and Ar+ ions. Part I: nanoindentation with spherical tipped indenter [J]. Nucl. Instrum. Methods Phys. Res., 2004, 216B: 269
73 D'Alessio L, Ferro D, Marotta V, et al. Laser ablation and deposition of bioglass® 45S5 thin films [J]. Appl. Surf. Sci., 2001, 183: 10
74 Gnanavel S, Ponnusamy S, Mohan L, et al. Electrochemical behavior of biomedical titanium alloys coated with diamond carbon in Hanks' solution [J]. J. Mater. Eng. Perform., 2018, 27: 1635
75 Kaliaraj G S, Bavanilathamuthiah M, Kirubaharan K, et al. Bio-inspired YSZ coated titanium by EB-PVD for biomedical applications [J]. Surf. Coat. Technol., 2016, 307: 227
76 Paital S R, Dahotre N B. Calcium phosphate coatings for bio-implant applications: Materials, performance factors, and methodologies [J]. Mater. Sci. Eng., 2009, R66: 1
77 Oyane A, Wang X P, Sogo Y, et al. Calcium phosphate composite layers for surface-mediated gene transfer [J]. Acta Biomater., 2012, 8: 2034
78 Surmenev R A, Surmeneva M A, Ivanova A A. Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis—A review [J]. Acta Biomater., 2014, 10: 557
79 Liu B, Shi X M, Xiao G Y, et al. In-situ preparation of scholzite conversion coatings on titanium and Ti-6Al-4V for biomedical applications [J]. Colloids Surf., 2017, 153B: 291
80 Yu W Z, Zhang Y Z, Liu X M, et al. Synergistic antibacterial activity of multi components in lysozyme/chitosan/silver/hydroxyapatite hybrid coating [J]. Mater. Des., 2018, 139: 351
81 Liu X H, Wu L, Ai H J, et al. Cytocompatibility and early osseointegration of nano TiO2-modified Ti-24Nb-4Zr-7.9Sn surfaces [J]. Mater. Sci. Eng., 2015, C48: 256
82 Zhang X M, Li Z Y, Yuan X B, et al. Fabrication of dopamine-modified hyaluronic acid/chitosan multilayers on titanium alloy by layer-by-layer self-assembly for promoting osteoblast growth [J]. Appl. Surf. Sci., 2013, 284: 732
83 İzmir M, Ercan B. Anodization of titanium alloys for orthopedic applications [J]. Front. Chem. Sci. Eng., 2019, 13: 28
84 Minagar S, Berndt C C, Wang J, et al. A review of the application of anodization for the fabrication of nanotubes on metal implant surfaces [J]. Acta Biomater., 2012, 8: 2875
85 Schwartz Z, Olivares-Navarrete R, Wieland M, et al. Mechanisms regulating increased production of osteoprotegerin by osteoblasts cultured on microstructured titanium surfaces [J]. Biomaterials, 2009, 30: 3390
86 Kim M J, Kim C W, Lim Y J, et al. Microrough titanium surface affects biologic response in MG63 osteoblast-like cells [J]. J. Biomed. Mater. Res., 2006, 79A: 1023
87 Yu W Q, Jiang X Q, Zhang F Q, et al. The effect of anatase TiO2 nanotube layers on MC3T3-E1 preosteoblast adhesion, proliferation, and differentiation [J]. J. Biomed. Mater. Res., 2010, 94A: 1012
88 Zhao L Z, Mei S L, Chu P K, et al. The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions [J]. Biomaterials, 2010, 31: 5072
89 Huang X B, Liu Y P, Yu H W, et al. One-step fabrication of cytocompatible micro/nano-textured surface with TiO2 mesoporous arrays on titanium by high current anodization [J]. Electrochim. Acta, 2016, 199: 116
90 Hu N, Wu Y Z, Xie L X, et al. Enhanced interfacial adhesion and osseointegration of anodic TiO2 nanotube arrays on ultra-fine-grained titanium and underlying mechanisms [J]. Acta Biomater., 2020, 106: 360
91 Lee J K, Choi D S, Jang I, et al. Improved osseointegration of dental titanium implants by TiO2 nanotube arrays with recombinant human bone morphogenetic protein-2: A pilot in vivo study [J]. Int. J. Nanomedicine, 2015, 10: 1145
92 Su E P, Justin D E, Pratt C R, et al. Effects of titanium nanotubes on the osseointegration, cell differentiation, mineralisation and antibacterial properties of orthopaedic implant surfaces [J]. Bone Joint J., 2018, 100-B: 9
93 Kim S Y, Kim Y K, Park I S, et al. Effect of alkali and heat treatments for bioactivity of TiO2 nanotubes [J]. Appl. Surf. Sci., 2014, 321: 412
94 Kang M K, Moon S K, Kim K M, et al. Antibacterial effect and cytocompatibility of nano-structured TiO2 film containing Cl [J]. Dent. Mater. J., 2011, 30: 790
95 Liang Y Q, Yang X J, Cui Z D, et al. Self-organized nanotubular layer on Ti-4Zr-22Nb-2Sn alloys formed in organic electrolytes [J]. J. Mater. Res., 2009, 24: 3647
96 Shin K R, Kim Y S, Kim G W, et al. Effects of concentration of Ag nanoparticles on surface structure and in vitro biological responses of oxide layer on pure titanium via plasma electrolytic oxidation [J]. Appl. Surf. Sci., 2015, 347: 574
97 Kaluđerović M R, Schreckenbach J P, Graf H L. First titanium dental implants with white surfaces: Preparation and in vitro tests [J]. Dent. Mater., 2014, 30: 759
98 Wang H Y, Zhu R F, Lu Y P, et al. Preparation and properties of plasma electrolytic oxidation coating on sandblasted pure titanium by a combination treatment [J]. Mater. Sci. Eng., 2014, C42: 657
99 Hong M H, Lee D H, Kim K M, et al. Study on bioactivity and bonding strength between Ti alloy substrate and TiO2 film by micro-arc oxidation [J]. Thin Solid Films, 2011, 519: 7065
100 Wang R Y, He X J, Gao Y E, et al. Antimicrobial property, cytocompatibility and corrosion resistance of Zn-doped ZrO2/TiO2 coatings on Ti6Al4V implants [J]. Mater. Sci. Eng., 2017, C75: 7
101 Matos A O, Ricomini-Filho A P, Beline T, et al. Three-species biofilm model onto plasma-treated titanium implant surface [J]. Colloids Surf., 2017, 152B: 354
102 Zhang J, Tu Q S, Bonewald L F, et al. Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1 [J]. J. Bone Miner. Res., 2011, 26: 1953
103 Li Y, Fan L K, Liu S Y, et al. The promotion of bone regeneration through positive regulation of angiogenic-osteogenic coupling using microRNA-26a [J]. Biomaterials, 2013, 34: 5048
104 Suh J S, Lee J Y, Choi Y S, et al. Erratum to ‘Peptide-mediated intracellular delivery of miRNA-29b for osteogenic stem cell differentiation' [Biomaterials 34 (2013) 4347-4359] [J]. Biomaterials, 2014, 35: 5039
105 Meng Y B, Li X, Li Z Y, et al. Surface functionalization of titanium alloy with miR-29b nanocapsules to enhance bone regeneration [J]. ACS Appl. Mater. Interfaces, 2016, 8: 5783
106 Geng Z, Wang X G, Zhao J, et al. The synergistic effect of strontium-substituted hydroxyapatite and microRNA-21 on improving bone remodeling and osseointegration [J]. Biomater. Sci., 2018, 6: 2694
107 Geng Z, Yu Y M, Li Z Y, et al. Mir-21 promotes osseointegration and mineralization through enhancing both osteogenic and osteoclastic expression [J]. Mater. Sci. Eng., 2020, C111: 110785
108 Zhang X M, Zhu S L, Li Z Y, et al. Multilayer modification on titanium surface for in situ delivery of MicroRNAs [J]. Mater. Lett., 2014, 133: 243
109 Shahriyari F, Razaghian A, Taghiabadi R, et al. Effect of friction hardening pre-treatment on increasing cytocompatibility of alkali heat-treated Ti-6Al-4V alloy [J]. Surf. Coat. Technol., 2018, 353: 148
110 Sun Y S, Chang J H, Huang H H. Enhancing the biological response of titanium surface through the immobilization of bone morphogenetic protein-2 using the natural cross-linker genipin [J]. Surf. Coat. Technol., 2016, 303: 289
111 Hu H, Cui Z D, Zhu S L, et al. Preparation of hydroxyapatite layer on Ti-based bulk metallic glasses by acid and alkali pre-treatment [J]. Rare Met., 2015, 34: 22
112 Chen M F, Liu D B, You C, et al. Interfacial characteristic of graded hydroxyapatite and titanium thin film by magnetron sputtering [J]. Surf. Coat. Technol., 2007, 201: 5688
113 Li M, Li L Q, Su K, et al. Highly effective and noninvasive near-infrared eradication of a Staphylococcus aureus biofilm on implants by a photoresponsive coating within 20 min [J]. Adv. Sci., 2019, 6: 1900599
114 Tan L, Li J, Liu X M, et al. Rapid biofilm eradication on bone implants using red phosphorus and near-infrared light [J]. Adv. Mater., 2018, 30: 1801808
115 Hosseinabadi H N, Sajjady S A, Amini S. Creating micro textured surfaces for the improvement of surface wettability through ultrasonic vibration assisted turning [J]. Int. J. Adv. Manuf. Technol., 2018, 96: 2825
116 Gao X J, Tong W J, Ouyang X P, et al. Facile fabrication of a superhydrophobic titanium surface with mechanical durability by chemical etching [J]. RSC Adv., 2015, 5: 84666
117 Hou X M, Wang X B, Zhu Q S, et al. Preparation of polypropylene superhydrophobic surface and its blood compatibility [J]. Colloids Surf., 2010, 80B: 247
118 Tang P F, Zhang W, Wang Y, et al. Effect of superhydrophobic surface of titanium on Staphylococcus aureus adhesion [J]. J. Nanomater., 2011, 2011: 178921
119 Zhang X, Wan Y, Ren B, et al. Preparation of superhydrophobic surface on titanium alloy via micro-milling, anodic oxidation and fluorination [J]. Micromachines, 2020, 11: 316
120 Patiño-Herrera R, González-Alatorre G, Estrada-Baltazar A, et al. Hydrophobic coatings for prevention of dental enamel erosion [J]. Surf. Coat. Technol., 2015, 275: 148
121 Mi G J, Shi D, Wang M, et al. Reducing bacterial infections and biofilm formation using nanoparticles and nanostructured antibacterial surfaces [J]. Adv. Healthc. Mater., 2018, 7: 1800103
122 Kingshott P, Wei J, Bagge-Ravn D, et al. Covalent attachment of poly(ethylene glycol) to surfaces, critical for reducing bacterial adhesion [J]. Langmuir, 2003, 19: 6912
123 Harris L G, Tosatti S, Wieland M, et al. Staphylococcus aureus adhesion to titanium oxide surfaces coated with non-functionalized and peptide-functionalized poly(l-lysine)-grafted-poly(ethylene glycol) copolymers [J]. Biomaterials, 2004, 25: 4135
124 Yang F, Williams C G, Wang D A, et al. The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells [J]. Biomaterials, 2005, 26: 5991
125 Ding X, Yang C, Lim T P, et al. Antibacterial and antifouling catheter coatings using surface grafted PEG-b-cationic polycarbonate diblock copolymers [J]. Biomaterials, 2012, 33: 6593
126 Yang C, Ding X, Ono R J, et al. Brush-like polycarbonates containing dopamine, cations, and PEG providing a broad-spectrum, antibacterial, and antifouling surface via one-step coating [J]. Adv. Mater., 2014, 26: 7346
127 Li L L, Qi G B, Yu F Q, et al. An adaptive biointerface from self-assembled functional peptides for tissue engineering [J]. Adv. Mater., 2015, 27: 3181
128 Ivanova E P, Hasan J, Webb H K, et al. Bactericidal activity of black silicon [J]. Nat. Commun., 2013, 4: 2838
129 Mainwaring D E, Nguyen S H, Webb H, et al. The nature of inherent bactericidal activity: Insights from the nanotopology of three species of dragonfly [J]. Nanoscale, 2016, 8: 6527
130 Li J, Tan L, Liu X M, et al. Balancing bacteria-osteoblast competition through selective physical puncture and biofunctionalization of ZnO/polydopamine/arginine-glycine-aspartic acid-cysteine nanorods [J]. ACS Nano, 2017, 11: 11250
131 Zhong Z X, Xu Z, Sheng T, et al. Unusual air filters with ultrahigh efficiency and antibacterial functionality enabled by ZnO nanorods [J]. ACS Appl. Mater. Interfaces, 2015, 7: 21538
132 Nguyen M N, Lebarbe T, Zouani O F, et al. Impact of RGD nanopatterns grafted onto titanium on osteoblastic cell adhesion [J]. Biomacromolecules, 2012, 13: 896
133 Bellis S L. Advantages of RGD peptides for directing cell association with biomaterials [J]. Biomaterials, 2011, 32: 4205
134 Swartjes J J T M, Das T, Sharifi S, et al. A functional DNase I coating to prevent adhesion of bacteria and the formation of biofilm [J]. Adv. Funct. Mater., 2013, 23: 2843
135 Flemming H C, Wingender J. The biofilm matrix [J]. Nat. Rev. Microbiol., 2010, 8: 623
136 Arciola C R, Campoccia D, Montanaro L. Implant infections: Adhesion, biofilm formation and immune evasion [J]. Nat. Rev. Microbiol., 2018, 16: 397
137 Chen Z W, Ji H W, Liu C Q, et al. A multinuclear metal complex based dnase-mimetic artificial enzyme: Matrix cleavage for combating bacterial biofilms [J]. Angew. Chem. Int. Ed., 2016, 55: 10732
138 Liu Z W, Wang F M, Ren J S, et al. A series of MOF/Ce-based nanozymes with dual enzyme-like activity disrupting biofilms and hindering recolonization of bacteria [J]. Biomaterials, 2019, 208: 21
139 Miller M B, Bassler B L. Quorum sensing in bacteria [J]. Annu. Rev. Microbiol., 2001, 55: 165
140 Waters C M, Bassler B L. Quorum sensing: Cell-to-cell communication in bacteria [J]. Annu. Rev. Cell. Dev. Biol., 2005, 21: 319
141 Flickinger S T, Copeland M F, Downes E M, et al. Quorum sensing between Pseudomonas aeruginosa biofilms accelerates cell growth [J]. J. Am. Chem. Soc., 2011, 133: 5966
142 Sun Y H, Qin H S, Yan Z Q, et al. Combating biofilm associated infection in vivo: Integration of quorum sensing inhibition and photodynamic treatment based on multidrug delivered hollow carbon nitride sphere [J]. Adv. Funct. Mater., 2019, 29: 1808222
143 Vermote A, Brackman G, Risseeuw M D P, et al. Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus [J]. Angew. Chem. Int. Ed., 2016, 55: 6551
144 Ivanova K, Fernandes M M, Mendoza E, et al. Enzyme multilayer coatings inhibit Pseudomonas aeruginosa biofilm formation on urinary catheters [J]. Appl. Microbiol. Biotechnol., 2015, 99: 4373
145 Yuan Z, He Y, Lin C C, et al. Antibacterial surface design of biomedical titanium materials for orthopedic applications [J]. J. Mater. Sci. Technol., 2021, 78: 51
146 Handke L D, Rogers K L, Olson M E, et al. Staphylococcus epidermidis saeR is an effector of anaerobic growth and a mediator of acute inflammation [J]. Infect. Immun., 2008, 76: 141
147 Yang S B, Han X G, Yang Y, et al. Bacteria-targeting nanoparticles with microenvironment-responsive antibiotic release to eliminate intracellular Staphylococcus aureus and associated infection [J]. ACS Appl. Mater. Interfaces, 2018, 10: 14299
148 Chatterjee S S, Joo H S, Duong A C, et al. Essential Staphylococcus aureus toxin export system [J]. Nat. Med., 2013, 19: 364
149 Sutrisno L, Hu Y, Shen X K, et al. Fabrication of hyaluronidase-responsive biocompatible multilayers on BMP2 loaded titanium nanotube for the bacterial infection prevention [J]. Mater. Sci. Eng., 2018, C89: 95
150 Zhuk I, Jariwala F, Attygalle A B, et al. Self-defensive layer-by-layer films with bacteria-triggered antibiotic release [J]. ACS Nano, 2014, 8: 7733
151 Yuan Z, Huang S Z, Lan S X, et al. Surface engineering of titanium implants with enzyme-triggered antibacterial properties and enhanced osseointegration in vivo [J]. J. Mater. Chem., 2018, 6B: 8090
152 Jia Z J, Xiu P, Li M, et al. Bioinspired anchoring AgNPs onto micro-nanoporous TiO2 orthopedic coatings: Trap-killing of bacteria, surface-regulated osteoblast functions and host responses [J]. Biomaterials, 2016, 75: 203
153 Lin X, Yang S F, Lai K, et al. Orthopedic implant biomaterials with both osteogenic and anti-infection capacities and associated in vivo evaluation methods [J]. Nanomed: Nanotechnol. Biol. Med., 2017, 13: 123
154 Afewerki S, Bassous N, Harb S, et al. Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications [J]. Nanomed: Nanotechnol., Biol. Med., 2020, 24: 102143
155 Wang Z M, Wang K F, Lu X, et al. Nanostructured architectures by assembling polysaccharide-coated BSA nanoparticles for biomedical application [J]. Adv. Healthc. Mater., 2015, 4: 927
156 Min J, Choi K Y, Dreaden E C, et al. Designer dual therapy nanolayered implant coatings eradicate biofilms and accelerate bone tissue repair [J]. ACS Nano, 2016, 10: 4441
157 Verlee A, Mincke S, Stevens C V. Recent developments in antibacterial and antifungal chitosan and its derivatives [J]. Carbohydr. Polym., 2017, 164: 268
158 Chua P H, Neoh K G, Kang E T, et al. Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion [J]. Biomaterials, 2008, 29: 1412
159 Ordikhani F, Tamjid E, Simchi A. Characterization and antibacterial performance of electrodeposited chitosan-vancomycin composite coatings for prevention of implant-associated infections [J]. Mater. Sci. Eng., 2014, C41: 240
160 Lin J, Qiu S Y, Lewis K, et al. Mechanism of bactericidal and fungicidal activities of textiles covalently modified with alkylated polyethylenimine [J]. Biotechnol. Bioeng., 2003, 83: 168
161 Atar-Froyman L, Sharon A, Weiss E I, et al. Anti-biofilm properties of wound dressing incorporating nonrelease polycationic antimicrobials [J]. Biomaterials, 2015, 46: 141
162 Asri L A T W, Crismaru M, Roest S, et al. A shape-adaptive, antibacterial-coating of immobilized quaternary-ammonium compounds tethered on hyperbranched polyurea and its mechanism of action [J]. Adv. Funct. Mater., 2014, 24: 346
163 Wei T, Zhan W J, Yu Q, et al. Smart biointerface with photoswitched functions between bactericidal activity and bacteria-releasing ability [J]. ACS Appl. Mater. Interfaces, 2017, 9: 25767
164 Zasloff M. Antimicrobial peptides of multicellular organisms [J]. Nature, 2002, 415: 389
165 Reddy K V R, Yedery R D, Aranha C. Antimicrobial peptides: Premises and promises [J]. Int. J. Antimicrob. Agents, 2004, 24: 536
166 Brogden K A. Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? [J]. Nat. Rev. Microbiol., 2005, 3: 238
167 Campoccia D, Montanaro L, Arciola C R. A review of the biomaterials technologies for infection-resistant surfaces [J]. Biomaterials, 2013, 34: 8533
168 Mellier C, Fayon F, Boukhechba F, et al. Design and properties of novel gallium-doped injectable apatitic cements [J]. Acta Biomater., 2015, 24: 322
169 Mei S L, Wang H Y, Wang W, et al. Antibacterial effects and biocompatibility of titanium surfaces with graded silver incorporation in titania nanotubes [J]. Biomaterials, 2014, 35: 4255
170 Zhang L, Gao Q, Han Y. Zn and Ag co-doped anti-microbial TiO2 coatings on Ti by micro-arc oxidation [J]. J. Mater. Sci. Technol., 2016, 32: 919
171 Sedelnikova M B, Komarova E G, Sharkeev Y P, et al. Modification of titanium surface via Ag-, Sr- and Si-containing micro-arc calcium phosphate coating [J]. Bioact. Mater., 2019, 4: 224
172 Roknian M, Fattah-alhosseini A, Gashti S O, et al. Study of the effect of ZnO nanoparticles addition to PEO coatings on pure titanium substrate: Microstructural analysis, antibacterial effect and corrosion behavior of coatings in ringer's physiological solution [J]. J. Alloys Compd., 2018, 740: 330
173 Liu W W, Su P L, Chen S, et al. Synthesis of TiO2 nanotubes with ZnO nanoparticles to achieve antibacterial properties and stem cell compatibility [J]. Nanoscale, 2014, 6: 9050
174 Maimaiti B, Zhang N Y, Yan L, et al. Stable ZnO-doped hydroxyapatite nanocoating for anti-infection and osteogenic on titanium [J]. Colloids Surf., 2020, 186B: 110731
175 Ma Z, Ren L, Shahzad M B, et al. Hot deformation behavior of Cu-bearing antibacterial titanium alloy [J]. J. Mater. Sci. Technol., 2018, 34: 1867
176 Liu H, Liu R, Ullah I, et al. Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity [J]. J. Mater. Sci. Technol., 2020, 48: 130
177 Liu R, Tang Y L, Liu H, et al. Effects of combined chemical design (Cu addition) and topographical modification (SLA) of Ti-Cu/SLA for promoting osteogenic, angiogenic and antibacterial activities [J]. J. Mater. Sci. Technol., 2020, 47: 202
178 Agarwal A, Weis T L, Schurr M J, et al. Surfaces modified with nanometer-thick silver-impregnated polymeric films that kill bacteria but support growth of mammalian cells [J]. Biomaterials, 2010, 31: 680
179 Cheng H, Xiong W, Fang Z, et al. Strontium (Sr) and silver (Ag) loaded nanotubular structures with combined osteoinductive and antimicrobial activities [J]. Acta Biomater., 2016, 31: 388
180 Tîlmaciu C M, Mathieu M, Lavigne J P, et al. In vitro and in vivo characterization of antibacterial activity and biocompatibility: A study on silver-containing phosphonate monolayers on titanium [J]. Acta Biomater., 2015, 15: 266
181 van Hengel I A J, Putra N E, Tierolf M W A M, et al. Biofunctionalization of selective laser melted porous titanium using silver and zinc nanoparticles to prevent infections by antibiotic-resistant bacteria [J]. Acta Biomater., 2020, 107: 325
182 Shen X K, Hu Y, Xu G Q, et al. Regulation of the biological functions of osteoblasts and bone formation by Zn-incorporated coating on microrough titanium [J]. ACS Appl. Mater. Interfaces, 2014, 6: 16426
183 Jin G D, Cao H L, Qiao Y Q, et al. Osteogenic activity and antibacterial effect of zinc ion implanted titanium [J]. Colloids Surf., 2014, 117B: 158
184 Huo K F, Zhang X M, Wang H R, et al. Osteogenic activity and antibacterial effects on titanium surfaces modified with Zn-incorporated nanotube arrays [J]. Biomaterials, 2013, 34: 3467
185 Liu P, Zhao Y C, Yuan Z, et al. Construction of Zn-incorporated multilayer films to promote osteoblasts growth and reduce bacterial adhesion [J]. Mater. Sci. Eng., 2017, C75: 998
186 Wu M C, Deokar A R, Liao J H, et al. Graphene-based photothermal agent for rapid and effective killing of bacteria [J]. ACS Nano, 2013, 7: 1281
187 Wang C, Wang Y L, Zhang L L, et al. Pretreated macrophage-membrane-coated gold nanocages for precise drug delivery for treatment of bacterial infections [J]. Adv. Mater., 2018, 30: 1804023
188 Qiao Y, Ping Y, Zhang H B, et al. Laser-activatable CuS nanodots to treat multidrug-resistant bacteria and release copper ion to accelerate healing of infected chronic nonhealing wounds [J]. ACS Appl. Mater. Interfaces, 2019, 11: 3809
189 Yin W Y, Yu J, Lv F T, et al. Functionalized nano-MoS2 with peroxidase catalytic and near-infrared photothermal activities for safe and synergetic wound antibacterial applications [J]. ACS Nano, 2016, 10: 11000
190 Cheng W, Zeng X W, Chen H Z, et al. Versatile polydopamine platforms: Synthesis and promising applications for surface modification and advanced nanomedicine [J]. ACS Nano, 2019, 13: 8537
191 Lei W X, Ren K F, Chen T T, et al. Polydopamine nanocoating for effective photothermal killing of bacteria and fungus upon near-infrared irradiation [J]. Adv. Mater. Interfaces, 2016, 3: 1600767
192 Yuan Z, Tao B L, He Y, et al. Biocompatible MoS2/PDA-RGD coating on titanium implant with antibacterial property via intrinsic ROS-independent oxidative stress and NIR irradiation [J]. Biomaterials, 2019, 217: 119290
193 Xie X Z, Mao C Y, Liu X M, et al. Synergistic bacteria killing through photodynamic and physical actions of graphene oxide/Ag/collagen coating [J]. ACS Appl. Mater. Interfaces, 2017, 9: 26417
194 Wang D, Niu L J, Qiao Z Y, et al. Synthesis of self-assembled porphyrin nanoparticle photosensitizers [J]. ACS Nano, 2018, 12: 3796
195 Zhu Y W, Xu C, Zhang N, et al. Polycationic synergistic antibacterial agents with multiple functional components for efficient anti-infective therapy [J]. Adv. Funct. Mater., 2018, 28: 1706709
196 Deng Q Q, Sun P P, Zhang L, et al. Porphyrin MOF dots-based, function-adaptive nanoplatform for enhanced penetration and photodynamic eradication of bacterial biofilms [J]. Adv. Funct. Mater., 2019, 29: 1903018
197 Su K, Tan L, Liu X M, et al. Rapid photo-sonotherapy for clinical treatment of bacterial infected bone implants by creating oxygen deficiency using sulfur doping [J]. ACS Nano, 2020, 14: 2077
198 Feng Z Z, Liu X M, Tan L, et al. Electrophoretic deposited stable chitosan@MoS2 coating with rapid in situ bacteria-killing ability under dual-light irradiation [J]. Small, 2018, 14: 1704347
199 Yuan Z, Tao B L, He Y, et al. Remote eradication of biofilm on titanium implant via near-infrared light triggered photothermal/photodynamic therapy strategy [J]. Biomaterials, 2019, 223: 119479
文章导航

/