可降解镁基复合材料的制备及其在骨科领域的研究进展

欧阳思慧, 佘加, 陈先华, 潘复生

Preparation of Biodegradable Mg-Based Composites and Their Recent Advances in Orthopedic Applications

OUYANG Sihui, SHE Jia, CHEN Xianhua, PAN Fusheng

表1 医用镁基复合材料中典型增强体类别及其力学性能和生物学性能^[60~72]

Table 1 Classifications of reinforcements in Mg-based composites and corresponding mechanical and biological properties of the composites for biomedical applications^[60-72]

Classification	Reinfor-cement	Mechanical property	Biological property	Application	Ref.
Metal oxide	Al₂O₃	E = 50 GPa, σ_ys = 176 MPa, σ_UCS = 486 MPa, ε = 14.0%	Improves protein adsorption, cell adhesion, and proliferation	Bone screws, bone plates, and knee prosthesis	[61]


	ZrO₂	σ_ys = 160 MPa, σ_UTS = 328 MPa, ε = 11.5%	Bio-inert and nontoxic to fibroblast and blood cells, improves cell viability, and greater bone stability	Artificial knee, femoral head, and bone screw	[62]


	ZnO	σ_ys = 89 MPa, σ_UTS = 94 MPa, ε = 1.7%	Cytocompatibility and hemocompatibility	Bone screws, bone plates	[63]


	MgO	σ_ys= 281 MPa, σ_UTS = 386 MPa, ε = 8.5%	Biodegradability, bioactivity, and good antibacterial properties	Prevent dental and orthopaedic infections	[64]


Metal	Ti	σ_ys = 134 MPa, σ_UCS = 418 MPa, ε = 51.0%	Biocompatibility and good antibacterial properties	Bone tissue and joint replacements	[65]


	Fe	σ_UTS = 178 MPa, ε = 1.9%	Biodegradability and good antibacterial properties	Bone graft	[66]


	Cu	σ_ys = 237 MPa, σ_UTS = 286 MPa, ε = 5.4%	Good antibacterial properties	Prevent dental and orthopaedic infections	[67]


Calcium	HA	σ_ys = 245 MPa, σ_UCS = 388 MPa, ε = 11.0%	Nontoxic and bioactive, excellent cell proliferation and osteoblastic differentiation, and reduces the release of Mg²⁺	Bone joint, bone screw, and pins	[68]
phosphate


	β-TCP	σ_UCS = 402 MPa, ε = 12.0%	Enhance bone adhesion and bone growth	Bone pin, bone screw	[69]


	CPP	E = 48 GPa, σ_ys = 320 MPa, σ_UTS = 337 MPa	Induce osteoblastic differentiation, do not cause inflammation, higher protein adsorption, and nontoxic to tissues	Bone tissue and joint replacements, dental implant	[60]



	FA	σ_ys = 107 MPa, σ_UCS = 123 MPa, ε = 5.0%	Enhance cell viability and osteoconductivity	Bone graft	[70]


Graphite	CNTs	σ_ys = 245 MPa, σ_UCS = 390 MPa, ε = 15.7%	Biocompatible even in blood contact, no tissue reaction, and nontoxic to cells	Bone screw, bone plates	[71]
	CNTs	σ_ys = 245 MPa, σ_UCS = 390 MPa, ε = 15.7%		Bone screw, bone plates	[71]
	GNPs	σ_ys = 230 MPa, σ_UTS = 407 MPa, ε = 13.0%	Hemocompatibility, cytocompatibility, and good antibacterial properties	Bone screw, bone plates	[72]
	GNPs	σ_ys = 230 MPa, σ_UTS = 407 MPa, ε = 13.0%		Bone screw, bone plates	[72]