可降解锌合金血管支架的研究现状、面临的挑战与对策思考

钱漪, 袁广银

Research Status, Challenges, and Countermeasures of Biodegradable Zinc-Based Vascular Stents

QIAN Yi, YUAN Guangyin

表1 可降解锌基合金在体内、体外降解速率[4,5,26~35]

Table 1 In vivo and in vitro degradation rate of degradable Zn-based alloy[4,5,26-35]

Alloy Preparation process In vitro (immersion test) In vivo Ref. mm·a-1 mm·a-1 Zn As-drawn 0.012 (45 d) [4] 0.05 (180 d) Zn-0.8Cu As-extruded & as-drawn 0.016 (180 d) [5] Zn-Li As-drawn 0.08 (60 d) [26] 0.046 (12 months) Zn As-extruded 0.022 SBF (20 d) [27] Zn-Mg As-extruded 0.084 Hank's (14 d) [28] Zn-Ag As-extruded 0.015 Hank's (28 d) [29] Zn-Cu As-extruded 0.033 SBF (20 d) [27] Zn-Ca As-rolled 0.089 Hank's (14 d) [30] Zn-Sr As-rolled 0.098 Hank's (14 d) [30] Zn-0.05Zr As-extruded 0.014 Hank's (28 d) [29] Zn-3Cu-0.1Mg As-extruded 0.022 Hank's (20 d) [31] Zn-3Cu-1Mg As-extruded 0.043 Hank's (20 d) [31] Zn-3Cu-0.5Fe As-extruded 0.064 SBF (20 d) [32] Zn-3Cu-1Fe As-extruded 0.069 SBF (20 d) [32] Zn-0.35Mn-0.41Cu As-rolled 0.050 SBF (14 d) [33] Zn-0.75Mn-0.40Cu As-rolled 0.065 SBF (14 d) [33] Zn-1.5Mg-0.1Mn As-cast 0.080 Hank's (30 d) [34] 0.065 Hank's (90 d) Zn-Mg-0.1Mn As-rolled 0.115 Hank's (30 d) [34] 0.070 Hank's (90 d) Zn-Mg-Ca As-extruded 0.090 Hank's (56 d) [35] Zn-Mg-Sr As-extruded 0.095 Hank's (56 d) [35] Zn-Ca-Sr As-extruded 0.109 Hank's (56 d) [35] Zn-Ag-0.05Zr As-extruded 0.017 Hank's (28 d) [29]