增材制造可降解金属医用植入物

郑玉峰, 夏丹丹, 谌雨农, 刘云松, 徐钰倩, 温鹏, 田耘, 赖毓霄

Additively Manufactured Biodegrabable Metal Implants

ZHENG Yufeng, XIA Dandan, SHEN Yunong, LIU Yunsong, XU Yuqian, WEN Peng, TIAN Yun, LAI Yuxiao

表2 医用金属材料特点及其潜在应用[20,21]

Table 2 Characteristics and potential applications of metallic biomaterials[20,21]

Classification Material Benefit Limitation Application Bio-inert 316L SS Acceptable biocompatibility, good High elastic modulus, localized ● Joint arthroplasty metals corrosion resistance and MRI corrosion with pitting, crevices and ● Bone defect repair compatibility, low cost stress corrosion cracking ● Dental implant Co-Cr High mechanical strength, High elastic modulus, biological ● Dental (orthodontic alloys excellent corrosion, fatigue and toxicity wire) wear resistance ● Craniofacial ● Spinal ● Orthopedic Ti alloys Superior biocompatibility, good Poor tribological characteristics, ● Bone defect repair corrosion resistance, mechanical fatigue strength, expensive, ● Bone scaffold strength, light weight incompatibility between the ● Spinal fusion elastic modulus of bone and ● Joint arthroplasty the Ti implant material Biodegradable Mg- Good biocompatibility, Excessive degradation rate, high ● Cardiovascular stents based biodegradable in the physiological H2 gas evolution, unwanted pH ● Orthopedic fixation metals alloys environment, ability to stimulate increase in surrounding tissue, bone formation and elastic modulus premature loss of mechanical close to natural bone, MRI integrity before sufficient compatibility tissue healing Zn-based Intermediate corrosion rate (faster Age hardening, excessive release ● Cardiovascular stents alloys than Fe-based alloys, slower than of Zn2+ during degradation results ● Orthopedic fixation Mg-based alloys), fair in cytotoxicity in vitro and delayed compatibility, no gas evolution osseointegration in vivo Fe-based High strength, high ductility, MRI Low corrosion rate, high elastic ● Cardiovascular stents alloys compatibility, fair modulus biocompatibility, gas evolution