增材制造可降解金属医用植入物
郑玉峰, 夏丹丹, 谌雨农, 刘云松, 徐钰倩, 温鹏, 田耘, 赖毓霄

Additively Manufactured Biodegrabable Metal Implants
ZHENG Yufeng, XIA Dandan, SHEN Yunong, LIU Yunsong, XU Yuqian, WEN Peng, TIAN Yun, LAI Yuxiao
表1 可降解金属性能总结[12~17]
Table 1 Summary of biodegradable metals' properties[12-17]
PropertyPerformanceZinc and its alloysMagnesium andIron and its alloys
its alloys
MechanicalYield strength (YS) / MPa126-389149-293106-950
propertyUltimate tensile strength / MPa167-647199-350169-1550
Ultimate compressive strength / MPa99-45790-258312-696
Elongation / %6-848-281.3-94
Hardness44-217 HV35-90 HB175-428 HV
Elastic modulus / GPa94-11041-4577-211
CorrosionIn vitro corrosion rate (SBF,0.16-1.660.45-12.560.17-1.30
behaviorelectrochemical test) / (mm·a-1)
In vitro corrosion rate (SBF, static0.014-0.030.07-1.880.028-0.250
immersion test, 30-60 d) / (mm·a-1)
In vivo corrosion rate (rats femur0.13-0.260.36-1.58No significant
model, volume loss, 8-12 weeks)degradation
/ (mm·a-1)
TypeUniform corrosion/Localized corrosion/Uniform corrosion/
localized corrosion/pitting corrosionlocalized corrosion/
pitting corrosionpitting corrosion
Main cathodic reactionsRedox reactionHydrogenRedox reaction
evolution reaction
Gas in biodegradation productsNoneHydrogenNone
Soluble biodegradation productsZn2+, OH-Mg2+, OH-Fe2+, Fe3+, OH-
Insoluble biodegradation productsZn(OH)2/ZnOMg(OH)2/MgOFe(OH)3/Fe2O3/Fe3O4
BiocompatibilityEssential elements in boneYesYesNo
metabolism
Content in humans / g2254-5
Concentration in serum / (mmol·L-1)0.012-0.0170.73-1.060.009-0.029
Average daily intake in diet / mg8.63291.1
Recommended daily allowance / mg12-15280-3508-18[14]
IC50 osteoblasts / (mmol·L-1)0.09> 4.020.328-0.583

IC50 oascular endothelial cells /

(mmol·L-1)

0.1366.7
LD50 / (mmol·L-1)35050001300