Research Progress of Biodegradable Magnesium Alloys for Orthopedic Applications

doi:10.11900/0412.1961.2017.00247

Acta Metall Sin

2017, Vol. 53

Issue (10): 1168-1180 DOI: 10.11900/0412.1961.2017.00247

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Research Progress of Biodegradable Magnesium Alloys for Orthopedic Applications

Guangyin YUAN¹(

), Jialin NIU^1,²

1 National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China
2 Shanghai Innovation Medical Technology Co., Ltd., Shanghai 200232, China

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Guangyin YUAN, Jialin NIU. Research Progress of Biodegradable Magnesium Alloys for Orthopedic Applications. Acta Metall Sin, 2017, 53(10): 1168-1180.

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Abstract

Magnesium and its alloys exhibit high mechanical strength and good biocompatibility, and their modulus is similar to natural cortical bone, which could help to avoid the stress shielding effect. These advantages make them promising candidates for bone repair applications. This paper summarizes the advantages, history, challenges, and the recent research progress of biodegradable Mg alloys for orthopedic application. At last, it gives a detailed introduction of the latest researches of Shanghai Jiao Tong University on biodegradable Mg alloys, and related work to promote their clinical applications.

Key words: biodegradable Mg-based alloy bone fixation biodegradation behavior biocompatibility

Received: 22 June 2017

ZTFLH:

TG146.22

Fund: Supported by National High Technology Research and Development Program of China (No.2015AA033603), National Natural Science Foundation of China (No.51571143), Enterprise international cooperation project of Science and Technology Commission of Shanghai Municipality (No.17440730700);2017 Shanghai Outstanding Academic Leaders Plan (No.17XD1402100)

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	Guangyin YUAN
	Jialin NIU

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https://www.ams.org.cn/EN/10.11900/0412.1961.2017.00247 OR https://www.ams.org.cn/EN/Y2017/V53/I10/1168

Fig.1 Schematic diagram showing Mg²⁺ promoting osteogenic differentiation into new bone^[13](DRG—dorsal root ganglia, CGRP—calcitonin gene-related polypeptide-α, CALCRL—calcitonin receptor-like receptor, RAMP1—receptor activity-modifying protein 1, PDSC—periosteum-derived stem cell, cAMP—cyclic adenosine monophosphate, CREB1—cAMP-responsive element binding protein 1, SP7—osterix, TRPM7—transient receptor potential cation channel, subfamily M, member 7, MAGT1—magnesium transporter 1)

Fig.2 MAGNEZIX^? compression screw produced by Syntellix AG and its application in hallux valgus surgery^[30]

Fig.3 K-MET Mg-based screws produced by U&i company were used in hand fractures fixation^[33]

Fig.4 Optical images of JDBM and JDBM-DCPD samples

Fig.5 JDBM and JDBM-DCPD plates and screws (a), and implantation surgery procedure in rabbit tibia (b)

Fig.6 The images of JDBM and JDBM-DCPD screws after implanted in NZ rabbit tibia for different periods^[92]
(a) JDBM screw pre-implantation (b) 8 weeks for JDBM screw (c) 8 weeks for JDBM-DCPD screw (d) 18 weeks for JDBM-DCPD screw

Fig.7 The setup of four point bending test (a), and the residual bending strength of JDBM, JDBM-DCPD and WE43 plates after implanted in rabbit tibia for different period (b)

Fig.8 The implantation surgery of JDBM-DCPD screw in rabbit mandible bone^[93]

Fig.9 The residual volume of JDBM-DCPD screws implanted in NZ rabbit mandible at different time points^[94]

Fig.10 Histological images of JDBM-DCPD screw implanted in mandible bone for 18 months^[94] (NB—new bone, DP—degradation product, HC—Haversian canal, OB—osteoblast, OC—osteocyte)
(a) an overview (b, c) the peri-implant new bone tissue at screw head and screw thread

Fig.11 The PLA/DCPD bilayer coating on JDBM and its properties ^[95]

Fig.12 JDBM bone plates and screws produced by Shanghai Innovation Medical Technology Co., Ltd.
(a) bone screws (b) DCPD coated screws (c) bone screw and plate system

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