Development and Application of Novel Biomedical Titanium Alloy Materials

doi:10.11900/0412.1961.2017.00288

Acta Metall Sin

2017, Vol. 53

Issue (10): 1238-1264 DOI: 10.11900/0412.1961.2017.00288

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Development and Application of Novel Biomedical Titanium Alloy Materials

Zhentao YU^1,²(

), Sen YU^1,², Jun CHENG^1,², Xiqun MA^1,²

1 Northwest Institute for Non-Ferrous Metal Research, Xi'an 710016, China
2 Shaanxi Key Laboratory of Biomedical Metal Materials, Northwest Institute for Non-Ferrous Metal Research, Xi'an 710016, China

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Zhentao YU, Sen YU, Jun CHENG, Xiqun MA. Development and Application of Novel Biomedical Titanium Alloy Materials. Acta Metall Sin, 2017, 53(10): 1238-1264.

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Abstract

Biomedical titanium alloy materials have become the main raw materials for orthopedic, dental and cardiovascular implants or devices, but their biological and mechanical compatibility remains to be improved to meet the long-term safety and function in services for clinical application. Whether developing the novel medical titanium alloys with high-strength, low-modulus and other finer comprehensive performance, or upgrading and optimizing the traditional medical titanium alloys, it is the foundation and key to ensuring the structure homogeneity, high performance, versatility and low cost of biomedical titanium alloy materials and expanding its clinical application. The design, physical metallurgy, materials process, microstructure and properties, surface modification, advanced manufacturing and the clinical application of biomedical titanium alloys were introduced, and their latest research progress was reviewed in this paper, together with the recent advances in the author's R & D team. Finally, the further research and development trend of biomedical titanium alloys are summarized.

Key words: biomedical titanium alloy surgical implant biological and mechanical compatibility alloy design physical metallurgy ultrafine-grained material porous material surface modification

Received: 12 July 2017

ZTFLH:	TG146.2
	R318.08

Fund: Supported by National Natural Science Foundation of China (No.31400821), National Key Research and Development Program of China (No.2016YFC1102003), Key Science and Technology Innovation Team of Shaanxi Province (No.2016KCT-30) and Science and Technology Achievements Transformation Project of Shaanxi Province (No.2016KTCG01-04)

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	Zhentao YU
	Sen YU
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	Xiqun MA

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Table 1 Mechanical properties of some typical newly developed titanium alloys used for biomedical application

Table 2 Comparisons of several vacuum melting methods

Fig.1 TNTZ (Ti-29Nb-13Ta-4.6Zr) alloy
(a) ingot (b) macrostructure (c) microstructure (d) hot rolled plate (e) as rolled microstructure

Fig.2 Ingot (a), hot rolled bar (b) and as rolled microstructure (c) of Ti-3.5Cu alloy

Table 3 Chemical compositions of Ti-Zr system alloys (mass fraction / %)

Fig.3 Microstructures of Ti-5Nb (a), Ti-10Nb (b), Ti-15Nb (c), Ti-20Nb (d) and Ti-25Nb (e) alloys bar

Table 4 Mechanical properties of ultra fine grain TLM alloy foil

Fig.4 Macrostructure (a) and microstructure (b) of cylinder porous TLM alloy specimen with porosity 64.5%, and relationship between porosity and elastic modulus (c)

Fig.5 Phase composition (a) and room temperature mechanical properties (b) of TLM alloy after solution treatment (ST) and ageing treatment

Table 5 Biological evaluation relative standards of biomedical titanium alloy devices^[112]

Fig.6 Morphology of TLM alloy after surface dealloying

Fig.7 Porous TLM alloy implant materials with bone trabecula prepared by selective laser melting (SLM)

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